ABSTRACT
To evaluate subcutaneous pancreatic transplantation in an experimentally induced diabetes mellitus in golden hamsters. Many indexes [histological /using two stains, histochemical /using three enzymes, morphometrical and biochemical /blood glucose level] were employed in this assessment. Alloxan was used as beta-cytotoxic therapy [to induce diabetes mellitus], and cyclophosphamide was employed as immunosuppressive agent. High rate of success of transplantation [clearly evident by microscopical features of viable endocrine and exocrine tissue of transplanted pancreas and great tissue vascularization, normal enzymatic activities and significant lowering of blood glucose level] were elicited. Subcutaneous pancreatic transplantation should be thank about in treatment of diabetes mellitus