ABSTRACT
Diabetes mellitus [DM] is a group of metabolic diseases characterized by hyperglycaemia, defects in insulin secretion or both. Diabetic retinopathy [DR] is a one of the late complications of DM. Adhesion molecules [including sE-selectin] may have a role in the pathogenesis of diabetic retinopathy [DR] E-selectin are extracellular matrix proteins that attract leucocytes from the circulation, expressed on the cell surface and are shed into the plasma. Thus, sE-selectin plasma concentration may representative for endothelial activation, damage and turnover. Thus, the aim of this study was to evaluate the concentration of sE-seleclin in typel DM patients with or without retinopathy and to evaluate the relationship between sE-selectin and Glycated haemoglobin [HbA1c] and microalbuminuria and also, with correlation to duration and control of DM. Study was performed on 80 individuals divided into 4 groups: G1; 20 healthy control, G2; 20 patients with [IDDM]. With no DR: G3; 20 patients [IDDM] with NPDR and G4; 20 Patients [IDDM] with PDR. The study results showed the following findings: increased FBS, Glycated haemoglobin [HbA1c], microalbuminuria in diabetic patients [more in NPDR, PDR] than those control group and those without DR sE-selectin were raised in diabetic patients than control group. Also, sE-selectin were raised in diabetic patients with DR compared to those without DR Also, sE-selectin appeared to be related HbA1c levels