ABSTRACT
To study serum testosterone level, insulin sensitivity and their correlation in mild, severe pre-eclasmpsia and eclampsia compared to normal pregnant women. The study included sixty patients. All were primigravidae, in 3[rd] trimester, they were divided into two groups, the first was normal control group [15 cases] and the second group [45 cases] was subdivided equally into three subgroups mild, severe pre-eclampsia and eclamptic cases. All cases were subjected to fasting venous blood sampling to measure glucose, insulin, total and free testosterone. The mean fasting serum testosterone [total and free] increased in pre-eclamptic toxemia cases significantly compared to the control group and in between subgroups, P was = 0.027 and 0.000 respectively. The mean fasting insulin level increased in pre-eclamptic toxemia significantly compared to control group and in subgroups p= 0.013. Mean fasting levels of testosterone, [total and free] were significantly higher in primigravidae with pre-eclampsia-eclampsia syndrome than in normotensive women with similar gestational ages. Levels of mean fasting insulin also were significantly higher than normotensive women. So there is positive correlation between hyperandrogenism and hyperinsulinemia or insulin resistance in preeclampsia-eclampsia syndrome