ABSTRACT
Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with longterm damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Type 2 diabetes [T2D] is characterized by a condition of systemic low-grade inflammation. IL-8 is an important member of the chemokine family of proinflammatory chemotactic cytokines. IL-8 was initially characterized as a potent chemoattractant of neutrophils and was later shown to also activate neutrophils. IL-8 is also known to be a potent promoter of angiogenesis
Objective: It was the Assessment of Interleukin [8] in Type 2 Diabetes Mellitus
Patients and Methods: Serum IL 8 level in Type 2 Diabetes Mellitus. 30 patients compared to 30 normal individuals were included in this study
Results: There was a highly statistical significant difference between all patients and control groups as regard serum IL 8 level [mean of serum IL 8 in patients and control groups were 69.9 +/- 20.5 and 5.4 +/- 3.3 respectively, p= < 0.001]
Conclusion: Type 2 diabetes mellitus patients showed marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory state and metabolic control and therefore it may be used as a marker for the rate of development of diabeteic complications
ABSTRACT
Background: ficolin-2 is a kind of human serum complement lectin with a structure similar to mannan-binding lectin [MBL] and it has been implicated in innate immunity. Recent studies have shown that complement pathway activation may contribute to hepatitis. However, the relationship between ficolin-2 and viral hepatitis remains largely elusive
Aim of the work:this study aimed to determine the dynamics of ficolin-2 in patients with chronic hepatitis C
Patients and Methods: thirty patients who had not yet received therapy and twenty normal control subjects were included in this study. A sandwich enzyme-linked immunosorbent assay [ELISA] was used to measure the ficolin-2 concentrations in all serum samples of patients and 20 healthy donors
Results: we found that the concentrations of ficolin-2 were significantly higher in chronic hepatitis C patients with abnormal ALT values than in chronic hepatitis C patients with normal ALT values and healthy controls. Ficolin-2 concentrations in chronic hepatitis C patients with abnormal ALT values were positively correlated with ALT levels [*P <0.05]. Then, we found ficolin-2 concentrations in rapid viral response [RVR] group decreased significantly [*P <0.05], while in non-RVR group, ficolin-2 decreased slightly [P >0.05]
Conclusion:our findings suggested that early increased ficolin-2 is highly correlated with hepatic inflammation and rapid viral response