Immediate venous sequelae of intravenous administration of midazolam versus propofol. A light and electron microscopic study

Eighteen guinea-pigs were categorized into three groups I, II, and III [6 each]. Animals of group I were injected intravenously via the external jugular veins with midazolam, group II were injected with propofol, while group Ill were received normal saline as a control model. Light microscopy revealed mild oedema in venous wall in group I and II. While electron microscopy revealed the relative innocuousness of propofol compared with midazolam in equipotent doses, probably due to the effect of the fat emmulsion solvent of propofol. In addition to the isotonicity and pH neutrality of the later