Quality of life in systemic lupus erythematosus

To study quality of life in Systemic Lupus Erythematosus patients. And to assess the impact of the psychological state on quality of life in a group from these patients. The study included 50 patients with systemic lupus, Including 40 subjects divided into 20 normal control and 20 subjects with depressive disorders from the same age group. Who were subjected to Hamilton depression rating scale [HDRS], Minnesota Multiphase Personality Inventory [MMPI], Rating scales for psychopathological health status and Quality of life Scale. [PCASEE] questionnaire. There are statistically significant differences between SLE patients with psychiatric manifestations and those without psychiatric manifestations as regards the [HDRS] and [MMPI] scales regarding depression, hysteria, hypochondrasis, paranoia, psychoathenia, schizophrenia, social introversion, psychopathic, hypomania. Also, there is statistically significant difference between the patients group and control group regarding the total score of the physical item [somatic items] regarding quality of life scale. Also, there are statistically significant differences between both groups as regards economic problems, at affective problems and cognitive problems according to [PCASEE]. Quality of life in SLE patients with psychiatric manifestations was more impaired than the SLE patients without psychiatric manifestations in the following items: economic problems, cognitive functions and affective problems. That may help in explain that the psychiatric manifestation increase the degree of impairment and disability in patients of SLE. Also, SLE patients are more impaired in quality of life than the group of depression as regards the economic problems

Psychoimmunological aspect of systemic lupus erythematosus

To detect the most common psychiatric manifestations associated with systemic lupus Erythematosus. Also, to correlate between psychiatric manifestations and immunity. The study included 50 patients with systemic lupus, Including 40 subjects divided into 20 normal control and 20 subjects with depressive disorders who were subjected to Hamilton depression rating scale [HDRS], Minnesota MuItiphase Personality Inventory [MMPI], Immunological tests to detect immunogloblins IgG, IgM and antiribosomal P protein antibodies. The total frequency of antiribosomal antibodies in the group of SLE patients was [38%] compared to the group of control depression only one patient is strong positive while the group of normal control no persons are positive. All depressed patients had high serum level of IgG and 93.3% of the control normal had a higher level of IgG while 88% of the SLE patients had high lgG serum levels 28% of the SLE patients had high IgM serum levels compared to both groups of depression and control normal with no statistically significant. Also, there are non significant negative correlations between antiribosomal antibodies and paranoia, schizophrenia and non significant positive correlations between the antiribosomal antibodies and depression detected by NI MMPI. There are highly significant positive correlations between depression and the lgG. While there are significant negative correlations between the IgM and depression. There are statistically significant differences between SLE with psychiatric manifestations and SLE without psychiatric manifestations regarding HDRS and MMPI. There is high frequency of psychiatric manifestations in SLE patients and depression considered the most frequent psychiatric disorders in SLE patients. There are strong relation between disturbance in the immune system and psychiatric disorders proved by high level of immunogloblins in patients with depression. Also, there are high frequency of antiribosomal antibodies in patients of SLE but their relations with the development of psychiatric symptoms are still contradictory