Pregnancy outcome and feto-placental blood flow in hypotensive pregnant women

To examine the effect of maternal hypotension on the feto-placental blood 110w, placental morphology and pregnancy outcome. Observational [prospective]study. Bab El Shaareia and El Hussein University Hospitals, Cairo. The study population consisted of 267 singleton pregnant women between the 26th to 38th week. They were divided into: a study group consisted of 117 hypotensive women with BP?90/60mmHg and a control group of 150 normotensive women with BP between 140/90mmHg. For both groups foetal biophysical profile and Doppler study of the umbilical and middle cerebral arteries were performed every 2-4 weeks. We examined the gestational age at delivery, birth weight, mode of delivery, Apgar score, possible fetomaternal complications and placental gross and microscopical features. In the hypotensive group the mean maternal weight gain was less, the umbilical A/B and RI were higher, middle cerebral artery PI was lower, the biophysical profile was lower, gestational age at delivery, birth weight was lower, Apgar score at 1 min. Was lower, abnormal perinatal outcome were higher, while placental calcification was significantly increased, all when compared to the control group, on the other hand the mean maternal age, mode of delivery, Apgar score at 5min. and placental weight show no significant difference when compared to the control group. Hypotension during pregnancy is a risky condition which we have to care for and hypotensive pregnant women should be monitored all through pregnancy

Low molecular weight heparin for the management of venous thromboembolism in pregnancy

This study is aiming to evaluate the effect and dose of Anoxaparin given to pregnant women with acute venous thromboembolism. This Observational 'prospective' study was carried out at Bab-El Shaareyia university hospital-Cairo-Egypt and Maternity Hospital, Sabbah- Kuwait on 20 pregnant women aged 22-41 years, with acute venous thromboembolism verified by objective means. Patients were treated with Enoxaparin from diagnosis until delivery. Treatment was monitored with anti-activated factor xa [anti-xa] activity, and the dose was adjusted to achieve 0.5-l.0U/ml 2-3 hours post-injection. Non of the patients suffered recurrent venous thromboembolisn or major bleeding complications. In 9 of 13 women starting with conventional dose of Enoxaparin, dose escalation was necessary to reach target anti- xa activity. None of the 6 women who started with Enoxaparin required dose escalation. One women who started with 133iu/kg bd required dose reduction. Bioaccumulaton was not observed. This study suggests that Enoxaparin may be used for the treatment acute venous thromboembolism in pregnancy approximately 10-20% higher doses of Enoxaparin may he needed as compared with non-pregnant individuals

Effect of hysterectomy on ovarian blood supply and function

The objective of this study was to determine whether hysterectomy has an effect on ovarian blood supply and functions or not and to make a decision to preserve or remove apparently normal ovaries in premenopausal women. Fifty premenopausal women, where ovarian blood supply and function were assessed before and after hysterectomy, were included in this study. Transvaginal color Doppler resistance index values of ovarian artery and hormonal levels [E2, FSH and LH] were measured. At the end of the 6th postoperative month, all these measurements were repeated. Serum levels of all hormones remained unchanged for six months after surgery. There was no significant difference between the pre and postoperative resistance index of ovarian arteries