ABSTRACT
Background: There is controversy about the relationship between vitiligo and thyroid dysfunction
Objective: To evaluate the relationship between vitiligo and thyroid disorders
Patients and Methods: This was a case-control study carried out on individuals with vitiligo in 2004 in Zahedan, that had it for at least 6 months as cases and individuals without vitiligo considered as the control group [Age and sex were matched with case group]. T3, T4, TSH, T3RU in both groups were assessed and FTI was calculated. Then hypo-, hyper- and euthyroid states were determined based on FTI and T3 level [For T3 hyperthyroidism] and data were analyzed by conditional logistic regression
Results: Each study group consisted of 50 individual, 52% female and 48% male. In the patient group, 16% had thyroid dysfunction, 14% of which had hyperthyroidism and 2% hypothyroidism. In control group, 4% had thyroid dysfunction, 2% of which had hyperthyroidism and 2% hypothyroidism. In case group only one patient had signs and symptoms of hyperthyroidism but in control group none had clinical symptoms. With statistical analysis was done odds ratio=7 [P<0.05] and the difference was significant
Conclusion: Vitiligo patients should be evaluated for thyroid dysfunctions to prevent complications of thyroid disease