ABSTRACT
Acantholytic squamous cell carcinoma (ASCC) is an uncommon variant of SCC. It was first described by Lever in 1947. It usually develops on sun-exposed areas of older-aged individuals. Histologically, the tumor consists of a nodular, epidermal-derived proliferation that forms islands like structures. At least focally or sometimes extensively, the tumor cells show a loss of cell cohesion within the central gland-like or tubular spaces. The lesions present as slowly growing scaly and occasionally ulcerated papules or plaques. Areas of acantholysis may produce large intraepidermal cavities which may extend to the adjacent follicular structures. ASCC is rarely seen in the oral cavity. Here, we report an unusual case of ASCC of the oral cavity, which was initially misinterpreted as angiosarcoma on histopathology. Then, on immunohistochemistry, ASCC was confirmed.
ABSTRACT
Ectopic thymic tissue in the neck is rarely reported in medical literature. Being uncommon, they are rarely included in the clinical diagnosis of cervical cystic masses and are misdiagnosed by surgeons as branchial cysts, lymphatic malformations, epidermoid cysts, dermoid cysts or thyroglossal cysts, lymphadenitis or neoplastic masses. Although it is rare, cervical thymic cyst should be considered in the differential diagnosis of a lateral cystic neck mass. Here we report a rare case of thymic cyst in a young 15-year-old male child on the left side of the neck. Histopathology of the excised cyst revealed thymic tissue composed of prominent Hassall's corpuscles, cholesterol clefts, lymphoid aggregates and cyst lined by cuboidal and squamous cells.
ABSTRACT
Background & objectives: The present study was undertaken to find out a new easy method in the diagnosis of malaria by centrifuged buffy coat smear, which was found to be a feasible and reasonable procedure. Methods: Blood samples collected from 120 patients suspected of malaria were subjected to all three diagnostic modalities—peripheral blood smear (PS), centrifuged buffy coat smear (CBCS) and antigen detection test using pLDH and aldolase (AG). Results: The results of various methods were compared. It was seen that addition of centrifugation (i.e. CBCS) to conventional method of PS (i.e. thick and thin smears) improved its sensitivity from 85 to 93.3%. Antigen detection and CBCS were found superior to PS in sensitivity. CBCS gives combined sensitivity and specificity of both antigen and PS. Conclusion: CBCS is as sensitive as antigen test and as specific as PS in species identification. It is a reasonable and feasible procedure too.
ABSTRACT
Carcinoma en cuirasse is a form of cutaneous metastasis. Although this condition is rare, it is most commonly associated with breast carcinoma with local recurrence after mastectomy. Cutaneous metastasis presents most commonly a few months or years after the primary has been diagnosed. Less frequently a metastasis is diagnosed at the same time as the primary tumor or presents as the first manifestation of the disease. We report a case of carcinoma en cuirasse in a 50-year-old female who presented with elevated, finely nodular, indurated skin lesions on left anterior chest wall, axillary region and keloid - like patch on left upper arm. On further examination a breast mass was detected. Fine needle aspiration of all the lesions was performed. Cytodiagnosis was given as infiltrating duct carcinoma of breast with metastatic carcinoma involving left anterior chest wall, axilla and left upper arm. We should not disregard keloid-like or indurated patches on skin which should be investigated thoroughly.
ABSTRACT
A case of a female patient aged 60 yrs, with metaplastic carcinoma of the breast which is a rare neoplasm is presented. Although it is a tumor of the ductal type, the predominant component of the neoplasm has an appearance other than glandular pattern and more in keeping with other cell types. Metaplastic carcinoma runs a very aggressive course and bears an unfavourable prognosis.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal/pathology , Carcinosarcoma/pathology , Diagnosis, Differential , Female , Humans , Metaplasia , Middle AgedABSTRACT
Retinal dysplasia is an uncommon condition and may be either unilateral or bilateral. It represents disturbed differentiation of neural ectoderm. It can be sporadic or may be associated with genetic defects. A case of unilateral retinal dysplasia in a 2 year old male child is reported.
Subject(s)
Child, Preschool , Humans , Male , Retina/pathology , Retinal Dysplasia/pathologyABSTRACT
A case of paratesticular liposarcoma in a 60 year male is presented for its rarity. The tumour was a dedifferentiated liposarcoma (DDL) seen in the original excision.
Subject(s)
Diagnosis, Differential , Humans , Liposarcoma/diagnosis , Male , Middle Aged , Orchiectomy , Scrotum/pathology , Testicular Neoplasms/diagnosis , Testis/pathologyABSTRACT
In the growing knowledge of rare interesting tumors, the cotyledonoid leiomyoma is a tumor with an alarming appearance, of benign nature, but dealt with undue severity. We report a case of cotyledonoid leiomyoma in a 40 yr old female who presented with urinary retention and in whom a clinical diagnosis of uterine fibroid was made. On laparotomy, friable nodules were seen in the lower part of the uterus. Hence the diagnosis of sarcoma was considered and total abdominal hysterectomy with unilateral salpingo-oopherectomy was done. The friable nodules were removed piecemeal. Microscopic examination revealed nodules of bland looking smooth muscle cells arranged in-interlacing fascicles with perinodular hydropic degeneration. Necrosis or nuclear atypia was not seen. Increased awareness of this grossly alarming variant of benign leiomyoma can help avoid over treatment.
Subject(s)
Adult , Diagnosis, Differential , Female , Humans , Leiomyoma/diagnosis , Leiomyosarcoma/diagnosis , Uterine Neoplasms/diagnosisABSTRACT
We report a case of nevus lipomatosus cutaneous superficialis, an uncommon hamartomatous disorder.