ABSTRACT
Context: reproductive domains of the Tehran lipid and glucose study [TLGS] are unique in that they provide reliable information on reproduction of an urban population ofWest Asia. The aim of this review is to present the most important reproductive findings of TLGS
Evidence Acquisition: this review is summarizing all articles published in the context of reproductive aspects of TLGS results over the 20-year follow-up. A comprehensive databases search was conducted in PubMed [including Medline], Web of Science and Scopus for retrieving articles on the reproductive histories in context of the TLGS
Results: the mean [SD] age at menarche and menopause was 13 [1.2] and 49.6 [4.5] years respectively. While pills were the most commonly used modern methods at the initiation of TLGS, the prevalence of condoms rose sharply and significantly over the follow up duration. Among women with history of gestational diabetes, the risk of diabetes and dyslipidemia progression were 2.44 and 1.2 fold higher than others. Prevalences of PCOS and idiopathic hirsutism among reproductive age participants of TLGS were 8.5% [95% CI: 6.8% - 10.2%] and 13.0% [95% CI: 10.9% - 15.1%], respectively. Trend of cardio-metabolic risk factors among women with PCOS showed that there were no statistically significant differences between mean changes of each cardio metabolic variables between PCOS and healthy women; PCOS status also significantly associated with increased hazard of diabetes and prediabetes among women aged younger than 40 years [HR: 4.9; 95% CI: 2.5 - 9.3, P value < 0.001]] and [HR: 1.7; 95% CI: 1.1 - 2.6], P value < 0.005], respectively
Conclusions: the population based nature of TLGS provides a unique opportunity for valid assessment of reproductive issues, the results of which could provide new information for modification of existing guidelines
ABSTRACT
Background: Infertility has a varied impact on multiple dimensions of health and functioning of women
Objective: We aimed to identify the burden of infertility and its influencing factors based on a population based study conducted in four provinces of Iran
Materials and Methods: A sample of 1126 women, aged 18-45 years, was selected using the multi stage, stratified probability sampling procedure; those met the eligibility criteria were invited for further comprehensive interview. This study used the definition of infertility proposed by World Health Organization "the woman has never conceived despite cohabitation and exposure to pregnancy for a period of 1 year"
Results: The overall prevalence of lifetime infertility and current primary infertility were 21.1% [95% CI: 18.4- 23.8] and 6.4% [95% CI: 4.8-8] respectively. The probability of first pregnancy at the end of 2 years of marriage was 94% for all ever-married women. Infertility were observed as significantly higher among women age 31-35 [OR: 4.6; 95% CI: 1.9-11.5; p=0.001] and women with more than 9 years of education [OR: 2.8; 95% CI: 1.5-3.3; p<0.0001]
Conclusion: The necessities of modern living have compelled many women to postpone childbearing to their late reproductive years; however they must be informed of being at risk of infertility with ageing