ABSTRACT
The autoimmune diseases tend to coexist with diabetes mellitus type I [T1DM]. The concomitance of these two types of diseases will lead to poor glycemic control beside their own complications. In this study the prevalence of thyroid disorder and celiac disease among T1DM patients in Yazd, Iran was evaluated. all the patients diagnosed as T1DM in Yazd younger than 18 years old were investigated for the presence of thyroid disorders and celiac by measuring T3, free T4, TSH, Anti TPO and anti-tTG IgA. In positive celiac disease laboratory tes, intestinal biopsy was done to confirm the presence of this disease. Data gathered from all patients were analyzed using SPSS software version 18th. Eighty one patients consist of 38 boys and 43 girls involved in our study. Six patients [7.4%] consist of 4 girls and 2 boys presented hypothyroidism with positive Anti TPO. Two patients [2.4%] presented positive anti-tTG IgA that both were confirmed by intestinal biopsy. due to the considerable prevalence of thyroid disorders and celiac disease among T1DM patients, serologically screening for autoimmune diseases and then annually for any new onset is suggested
ABSTRACT
Congenital hypothyroidis is a condition of thyroid hormone deficiency. Approximately 1 in 4000 newborn infants has a deficiency of thyroid function. The aim of this study is determination of the prevalence of permanent and transient congenital hypothyroidism [CH] in Yazd, Iran. From May 2006 to June 2008, 35377 newborns were screened by measuring serum TSH obtained by heel prick. The neonates who had a TSH >/=5mU/L were recalled for measurement of serum T4 and thyroid stimulating hormone [TSH] in venous samples. Based on the results of the secondary measurements [between days 7 and 28], neonates were considered hypothyroid if their T[4] was <6.5 mg/dl and their TSH was >/=10mIU/L. In 22 primarily diagnosed as cases of CH, treatment was discontinued at age 3 years for 4 weeks and T[4] and TSH were measured again. Permanent or transient CH was determined from the results of these tests; Patients with TSH levels >/=5 mIU/l were diagnosed with permanent CH. The incidence of congenital hypothyroidism was found to be 1:1608 with a female to male ratio of 0.69:1. In 22 patients with CH, 10 patients were diagnosed with permanent CH [45.5%] and 12 with transient hypothyroidism [54.5%]. Permanent CH was associated with higher TSH levels at first measurement than transient hypothyroidism [P-value=0.041]. The rate of transient CH in our study was higher than the comparable worldwide rate, so more and larger studies are needed to find clear information about the etiologic factors of this disease