ABSTRACT
Objective: To understand the status of autism spectrum disorder (ASD) cohort studies and explore the feasibility of constructing ASD disease-specific cohorts based on real-world data (RWD). Methods: ASD cohort studies published by December 2022 were collected by literature retrieval from major Chinese and English databases. And the characteristics of the cohort were summarized. Results: A total of 1 702 ASD cohort studies were included, and only 60 (3.53%) were from China. A total of 163 ASD-related cohorts were screened, of which 55.83% were birth cohorts, 28.22% were ASD-specific cohorts, and 4.91% were ASD high-risk cohorts. Most cohorts used RWD such as hospital registries or conducted community-based field surveys to obtain participant information and identified patients with ASD by scales or clinical diagnoses. The contents of the studies included ASD incidence and prognostic risk factors, ASD comorbidity patterns and the impact of ASD on self-health and their offspring's health. Conclusions: ASD cohort studies in developed countries have been in the advanced stage, while the Chinese studies are still in their infancy. RWD provides the data basis for ASD-specific cohort construction and offers new opportunities for research, but work such as case validation is still needed to ensure the scientific nature of cohort construction.
Subject(s)
Humans , Autism Spectrum Disorder , Cohort Studies , Databases, FactualABSTRACT
Objective To explore the effect of high resting heart rate (RHR) on the detection rate of carotid artery plaque in elderly population.Methods From June 2010 to June 2011,a total of 5 852 participants randomly selected and recruited from 101 510 workers of a Tangshan Kailuan Company in this cohort study.All the information was obtained through unified questionnaires.Blood tests and RHR were measured and color-ultrasound performed to detect the carotid artery plaque.All the subjects were divided into groups according to RHR,with ≤ 80 bpm/min as low RHR group and ＞80 bpm/min as high RHR group.The detection rates of carotid artery plaque were compared between the two groups after stratification on both gender and age.Single and multiple factors logistic regression analyses were used to analyze the factors related to carotid artery plaques.Results 1) The detection rate of carotid artery plaque in high RHR group was higher than that of low RHR group (48.9％ vs.41.5％,P＜0.001).Between the high or low RHR groups,the detection rates of carotid artery plaque were 58.7％ and 52.1％ in males,26.9％ and 25.1％ in females.2) The detection rates of carotid artery plaque increased with age:19.5％,42.9％,67.6％ and 86.5％ in ＜ 50,50-,60-and ≥ 70year olds.They were 25.1％,50.0％,70.5％ and 87.5％ in the high RHR group and,18.5％,41.8％,60.7％ and 86.3％ in the low RHR group.3) After adjustment for influence factors related to carotid artery plaque,the risk on carotid artery in high RHR group had an increase of 22.6％,when compared with that of the low RHR group.The OR value was 1.226(95％CI:1.018-1.477).Conclusion High RHR could increase the risk of carotid artery plaque.