ABSTRACT
OBJECTIVE: This study aimed at analyzing the rate of self-exclusion at the Regional Blood Bank in Montes Claros. METHODS: Data of self-excluding donors from August 2008 to August 2010 were analyzed. The following variables were considered: age, marital status, gender, ethnical background, blood group, Rh factor, number of donations, type of donation and serologic results. RESULTS: During the analyzed period, 34,778 individuals donated blood, 215 (0.62 percent) of which were self-excluded; 12 percent of donors did not answer, 6.3 percent ballots were spoilt and 13.6 percent of the responses were considered non-compliant. The profile of the donors was: male (81.9 percent), single (50.7 percent), aged between 19 and 29 years old (52.1 percent), Mulatto (48.3 percent), blood group O (32.1 percent) and positive Rh (32.1 percent). Most individuals were donating for the 2nd to 5th time (43.7 percent) and had negative serology (94.4 percent). CONCLUSIONS: It was not evident that self-excluding donors had higher rates of seropositivity.
Subject(s)
Animals , Blood , Blood Donors , Blood Transfusion , Donor Selection , SafetyABSTRACT
BACKGROUND: The development of therapies for sickle cell disease has received special attention, particularly those that reduce the polymerization of hemoglobin S. Hydroxyurea is a commonly used medication because it has the ability to raise levels of fetal hemoglobin, decrease the frequency of vaso-occlusive episodes and thus improve the clinical course of sickle cell disease patients. OBJECTIVE: To study hematological data and the clinical profile of sickle cell disease patients taking hydroxyurea in a regional blood center. METHODS: From the charts of 20 patients with sickle cell anemia, the clinical outcomes and a number of hematological variables were analyzed before and during treatment with hydroxyurea. RESULTS: The patients' ages ranged from 6 to 41 years old, most were dark skinned and there was a predominance of women. The main symptom that defined whether patients were prescribed hydroxyurea was painful crises followed by hospitalizations. During treatment with hydroxyurea there were significant increases in hemoglobin, fetal hemoglobin, mean corpuscular volume and mean corpuscular hemoglobin. The reticulocyte and white blood cell counts dropped significantly with treatment. A positive correlation was found between fetal hemoglobin and mean corpuscular volume before and during treatment. Additionally, a correlation was found between the white blood cell and reticulocyte counts before treatment with hydroxyurea. CONCLUSION: Most patients showed improvements with treatment as demonstrated by increases in hemoglobin, fetal hemoglobin and mean corpuscular volume, as well as by reductions in the reticulocyte and white blood cell counts. Clinically, more than 50 percent of patients had a significant reduction of events.
Subject(s)
Humans , Male , Female , Child , Adolescent , Young Adult , Anemia, Sickle Cell/therapy , Fetal Hemoglobin , Hydroxyurea/therapeutic useABSTRACT
A padronização e o controle da qualidade represetnam elementos imprescindíveis para a rotina laboratorial. Para cumprir a norma em vigor na rotina laboratorial. RDC 302/2005 e assegurar resultados confiáveis, o controle interno deve ser utilizado sistematicamente. O hemograma possui notável importância para o diagnóstico e controle evolutivo das doenças e no acompanhamento de tratamentos. O objetivo deste estudo foi determinar o intervalo de aceitabilidade para os parâmetros hematológicos (hemácias, hemoglobina, hematócritos, global de leucócitos e plaquetas) utilizando 50 amostras-controle de pacientes e doadores colhidas na Fundação Centro de Hematologia e Hemoterapia de Minas Gerais - Hemominas - Hemocentro Regional de Montes Claros. Os resultados obtidos neste estudo, demonstram a conformidade do uso uso das amostras-controle no controle da rotina hematológica, represetnando uma alternativa complementar de controle interno para laboratórios de análises clínicas.