Design and evaluation of dental pastes Containing anti-inflammatory drugs

Abstract Periodontitis is an oral disease associated with inflammation and pain with swollen and bleeding gums. In the present study, dental pastes containing NSAIDs, namely, diclofenac sodium and nimesulide (1 % w/w) were prepared to treat periodontitis. Dental pastes of diclofenac sodium and nimesulide (1 % w/w) were prepared with/without mucoadhesive hydrocolloid polymers such as sodium carboxy methyl cellulose (NaCMC), hydroxyl ethyl cellulose (HEC) and methyl cellulose (MC) by conventional trituration method. The pH, drug content, viscosity, tube spreadability and tube extrudability of these prepared dental pastes were measured. These dental pastes of diclofenac sodium and nimesulide (1 % w/w) were characterized by FTIR analyses for drug-excipient compatibility. The in vitro drug releases from these dental pastes in 6.4 pH phosphate buffer solution displayed sustained release over longer period and the drug release rate was found to be decreased when the concentration of mucoadhesive polymer was increased. These dental pastes displayed good adhesion to the oral mucosa revealing more retention time in mouth when tested for ex vivo mucoadhesion using bovine cheek pouch. The stability study results reveal that the DC3 and NC3 dental paste formulations were found stable enough over a longer period in different storage conditions. The present study revealed that the prepared mucoadhesive dental pastes of diclofenac sodium and nimesulide (1 % w/w) had good adhesion with the oral mucosa to maintain consistent release of drugs over prolonged time.

Biosynthesis of Silver Nanoparticles Using Tradescantia zebrina aqueous Leaf Extract and Their Antibacterial Activity

Biologically synthesized silver nanoparticles have emerged as one of the prime areas of investigation in recent years due to their wider application in biomedical and pharmaceutical sciences. In the present paper, we report the biosynthesis of silver nanoparticles using aqueous leaf extract of T. zebrina and its antibacterial activity against common human pathogenic bacteria such as Staphylococcus epidermidis, Staphylococcus aureus, Salmonella enterica, Escherichia coli and Bacillus cereus. The antibacterial activity of the biosynthesized silver nanoparticles were compared with amikacin which was used as the positive control. The results of the study revealed good zones of inhibitions of the nanoparticles against test organisms that were comparable to amikacin and hence has a great potential in the preparation of drugs used against bacterial diseases.

Biosynthesis and Assessment of Silver Nanoparticles with Sparfloxacin and Ofloxacin Synthesized from Penicillium Sp. on Some Bacterial Pathogens.

Here in this paper we have reported the extracellular biosynthesis of silver nanoparticles by using filamentous fungi Penicillium sp. The Penicillium sp. was isolated from the soil sample collected from vegetable market in Chennai, Tamil Nadu, India. The purified fungal culture was subjected for the biosynthesis of silver nanoparticles. The color change of the solution in the conical flask into dark brown suggests the formation of silver nanoparticles(AgNPs). These Silver nanoparticles have been further characterized by UV-vis spectrophotometer which showed the absorption peak at 416nm which confirms the nanoparticles synthesis, Fourier Transform Infrared (FTIR) Spectroscopy showed proteins and functional groups which stabilizes the nanoparticles as capping agent , Xray diffraction (XRD) analysis determine the crystalline nature of silver nanoparticles and Field emission scanning electron microscopy (FESEM) analysis which showed the particle size was around 35 to 67 nm and. These biologically synthesized silver nanoparticles showed good antibacterial activity against the selected bacterial pathogens and also these nanoparticles enhanced the antibacterial property of Sparfloxacin and Ofloxacin.