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IJRM-International Journal of Reproductive Biomedicine. 2013; 11 (1): 61-64
in English | IMEMR | ID: emr-193209

ABSTRACT

Background: recurrent pregnancy loss [RPL] caused by various genetic and non-genetic factors. After chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause RPL. Factor V Leiden and factor II G20210A mutation were the most common mutations cause thrombophilia in the world


Objective: the purpose of this study was to determine the frequency of factor V Leiden and prothrombin gene mutations in women with RPL compared with women who had uneventful pregnancies


Materials and Methods: this case control study evaluates the frequency of factor V-Leiden and factor II G20210 genotypes in 80 women with two or more pregnancy losses, compared with 80 women without adverse pregnancy outcome. The mutations were assessed by PCR-RFLP


Results: frequency of the factor V Leiden among cases was 2.5%, which was higher than controls [1.25%], but the difference was not significant. No factor II G20210 mutation was found among cases and controls


Conclusion: these data did not confirm that factor V Leiden and factor II G20210 mutation might play a role in recurrent pregnancy loss in Iranian women

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