ABSTRACT
The objective was to evaluate the sero-prevalence of hepatitis B surface antigen [HBsAg] and IgM antibodies to hepatitis core antigen in Balochistan Province of Pakistan. Design of the study: a cross-sectional, population-based study. Place and time of the study: The study was conducted in Balochistan from 1[st] January 2004 to 31[st] December, 2008. The screening areas included Barkhan, Eashani, Khuzdar, Kodi Zikriani, Kohlu, Rakhni and Turbat. A total of 15,260 subjects were enrolled; 11,900 [78%] agreed to undergo screening. Fresh serum samples were tested for the presence of hepatitis B surface antigen and IgM antibodies to hepatitis B core antigen. HBsAg was detected in 1166 [9.8%] while anti-HBc IgM was found in 117 [10.0%]. HBsAg positivity was seen in 875 [12.7%] males and 291 [5.8%] females. The prevalence of hepatitis B in Balochistan varies from 3.3% in Khuzdar to 17.0% in Kodi Zikriani. It is utmost important to educate the public, to take proper measures to control the spread of infection and vaccination in order to interrupt transmission of this threatening public health problem in Balochistan province of Pakistan