Effects of hemorrhage on myocardial metabolism

In vivo and in vitro studies were done to study the effects of severe haemorrhage [30%] of blood volume on cardiac metabolism. Induction of bleeding resulted in a significant increase in glucose uptake at 60 minutes post haemorrhage. Insignificant changes in pyruvate production and in glycerol release were observed Pre-treatments of rats with propranolol did not significantly affect the response of the heart to haemorrhage Also pretreatment with aprotinin resulted in only a significant release of glycerol by the heart In vitro results on the effects of shock plasma on the normal heart revealed an insignificant increase in glucose uptake and a significant glycerol release. The mechanisms underlying these effects are discussed