ABSTRACT
To determine the frequency and factors predisposing patients with type-Il diabetes mellitus to gallstones disease. Case-control study. Medical and surgical OPD, Chandka Medical College Hospital Larkana from January 2007 to December 2007. Total no: of 200 patients with one hundred diabetes mellitus type-2 with gallstones and one hundred age gender matched controls were taken. All the patients were examined for body mass index, waist hip ratio and investigated for blood sugar levels and lipid profile and pan abdomen ultrasound. Fifteen percent of diabetic patients had ultrasound evidence of gallstones as compared to 7% in non diabetic controls. There was significant increase in frequency of gallstones in diabetic patient's increasing age with peak incidence in seventh decade i.e. 60-69 years, and decline in 8th decade i.e. 70-79 years. The average age of diabetic patients with gallstones disease, was significantly higher than without gallstones disease. [p=-00 1]. The mean duration of disease in diabetic patients with gallstones disease was 5.0+ 4.8 years compared with 4.5+ 3.5 years in diabetic patients without gallstones disease [P=0.722]. The mean serum cholesterol and triglycerides levels 4.3.3 mmol/L and 1.5+ 0.8 mmol/L respectively in the diabetic patients with gallstones disease was higher than those without gallstones disease was higher than those without gallstones disease 3.4:f 0.5 mmol/L [P=0.0941] and 1.4 +/- 0.7 mmol/L [p=0-712] respectively, the mean body mass index with diabetic patients with gallstones disease was 26.2+ 5.5 kg/m2 compared with 25.7 +/- 6.7 kg/m2 in those without gallstones disease The frequency of gallstones disease in diabetes mellitus type II increasing with age female gender, obese hyperlipidemia and longer duration of disease