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Indian J Exp Biol ; 2000 Dec; 38(12): 1255-8
Article in English | IMSEAR | ID: sea-63417

ABSTRACT

Doses of titanium trichloride (1/10th and 1/5th of LD50) were administered once and daily to pregnant rats to assess their effect on embryonic development. 1/5th dose of TiCl3 administered once orally on 1st, 2nd and 3rd day post-coitum. Similarly 1/10th of LD50 was administered daily. Results revealed that 1/10th LD50 dose of TiCl3 was more effective during pre-implantation period as number of 4 and 8-celled embryos decreased as compared to 1/5th. Delayed hatching of the blastocysts on day 5 was registered in TiCl3 treated dam.


Subject(s)
Animals , Blastocyst/cytology , Cell Division/drug effects , Embryonic and Fetal Development/drug effects , Female , Lethal Dose 50 , Pregnancy , Rats , Titanium/administration & dosage
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