ABSTRACT
Introduction: Diabetic foot syndrome (DFS) is one of the mostserious, important and economically demanding complicationsthat patients with diabetes can develop. Hence; the presentstudy was undertaken for assessing and comparing the serumHbA1C level among patients with and without diabetic footcomplication.Materials & Methods: A total of 150 diabetic patients wereenrolled in the present study. Clinical examination was done inall the patients and prevalence of diabetic foot complicationwas assessed. Blood samples were withdrawn from all thepatients and mean HbA1c concentrations were assessed usingautoanalyzer. All the values were recorded in Microsoft excelsheet and were analysed by SPSS software. Chi- square testwas used for assessment of level of significance.Results: Prevalence of diabetic foot complication was found tobe present in 30 patients. Mean HbA1C values of patients withdiabetic foot complications was 10.75%, while among thepatients without diabetic foot complication, it was 8.76%. Whilecorrelation of occurrence of diabetic foot complication withdiabetic profile, significant results were obtained.Conclusion: Patients with diabetic foot complications areaccompanied by significant alteration in mean HbA1c levels.
ABSTRACT
Introduction: Hypertensive disorders in pregnancy are one ofthe leading causes of maternal and perinatal morbidity andmortality across the world. Hypoalbuminemia is not uncommonin women with the disease state whereas macroalbumiuria is apredictor of adverse pregnancy outcomes in the population.Hence; the present study was undertaken for assessmentserum albumin levels in pregnant hypertensive women.Materials & Methods: A total of 40 pregnant subjects wereanalysed. Among 40 subjects, 20 were hypertensive while theremaining 20 were non-hypertensive. Complete demographicdetails of all the patients were obtained. Blood samples wereobtained from all the patients and serum albumin levels wereassessed using autoanalyzer.Results: Mean age of the patients of the hypertensive andnon-hypertensive group was 59.6 years and 63.2 yearsrespectively. Mean serum albumin levels among the patients ofhypertensive and non-hypertensive group was 3.39 gm/dL and3.68 gm/dL respectively. Significant results were obtainedwhile comparing the mean serum albumin levels among thetwo study groups.Conclusion: Hypertensive pregnant subjects are accompaniedby significant alterations in serum albumin levels.
ABSTRACT
BACKGROUND AND OBJECTIVES: A large number of patients diagnosed with bone marrow failure syndromes (BMFS), comprising aplastic anaemia (AA) and myelodysplastic syndromes (MDS), remain aetiologically uncharacterized worldover, especially in resource constrained set up. We carried out this study to identify a few constitutional causes in BMFS patients attending a tertiary care hospital in north India. METHODS: Peripheral blood lymphocyte cultures were performed (with and without clastogens) in a cohort of 135 consecutive BMFS patients, in order to detect Fanconi anaemia (FA), Down's syndrome (+21), trisomy 8 (+8) and monosomy 7 (-7). RESULTS: Constitutional factors were detected in 17 (12.6%) patients. FA defect was observed in 24.07 percent (13/54), 16.66 percent (1/6) and 2.85 percent (1/35) paediatric aplastic anaemia, paediatric MDS and adult MDS patients respectively. Down's syndrome was detected in 5.00 percent (2/40) adult aplastic anaemia patients. None of the patients revealed trisomy 8 or monosomy 7. INTERPRETATION AND CONCLUSION: Presence of an underlying factor determines appropriate management, prognostication, family screening and genetic counselling of BMFS patients. Special tests required to confirm or exclude constitutional aetiological factors are not available to majority of the patients in our country. Diepoxybutane (DEB) test yielded better results than mitomycin C (MMC) test in our experience.