ABSTRACT
A solitary fibrous tumour (SFT) is an unusual spindle cell neoplasm that usually occurs in the pleura but has recently been described in diverse extrapleural sites. Urogenital localisation is rare, and to our knowledge, only 82 cases of SFT of the kidney have been described. Although SFT of the kidney is extremely rare, this tumour must be included in the differential diagnosis, whenever a renal tumour consisting of mesenchymal elements is encountered. We report a case of a large SFT of the left kidney which was clinically and radiologically thought to be a renal cell carcinoma, and a final diagnosis was made after immunohistochemical study.
ABSTRACT
Background: Imprint cytology plays a major role in rapid intraoperative diagnosis of lesions similar to frozen sections. Besides its speed and simplicity, it also provides excellent cellular details. Although histopathology is considered to be gold standard in diagnosis of ovarian neoplasms, yet the delay involved may at times affect the course of treatment. The optimal management of benign and malignant ovarian neoplasms is different especially in patients who want to retain fertility. This calls for a rapid intraoperative diagnosis which will decide further management. Aim and objectives: To study the imprint cytology of ovarian neoplasms and compare with histopathology findings, to establish the reliability of imprint smears in intraoperative diagnosis by statistical evaluation. Material and methods: The present study was done at MNJ Institute of Oncology, Hyderabad, a tertiary care center for period of one and half years i.e. from January 2017 to June 2018. The study was done on 40 fresh unfixed ovarian specimens sent for imprint cytology. Multiple imprint smears was taken from fresh resected masses after detailed gross examination. The findings were noted and compared to subsequent histopathology sections. Results: In the present study, out of 40 cases, 21 (52.5%) were benign, 9(22.5%) were borderline, 10(25%) were malignant based on imprint cytology smears. On histopathology sections, 22 (55%) were benign, 1(2.5%) was borderline and 17(42.5%) were malignant. The overall accuracy was 87.5% on imprint smears. Annapoorna Sireesha, B. Triveni, Sangeeta Parmer, K. Srilaxmi, Sai Mallikarjun. Role of Imprint cytology in rapid diagnosis of ovarian neoplasms with histopathology correlation. IAIM, 2018; 5(11): 56-62. Page 57 Conclusion: Imprint cytology is an excellent, simple, inexpensive, useful diagnostic tool in intraoperative diagnosis of ovarian neoplasms. This forms an important step in intraoperative decision-making for better management.
ABSTRACT
Materials and methods Retrospective study for period of 2 years was conducted. For this study, we reviewed bone marrow material along with nodal and extranodal tissues. There were 16 cases of mantle cell lymphoma (MCL). Each patient had an absolute lymphocyte count of more than 10 × 109/l at the time of initial evaluation at our institution. Giemsa stained peripheral blood and bone marrow aspirate smears were reviewed, along with haematoxylin-eosin-stained histologic sections of bone marrow aspiration and core biopsy specimens. The immuno-phenotype of the neoplastic cells supported the diagnosis of MCL. The clinical and pathological spectrum will be discussed. Immuno-histochemistry Immuno-histochemical staining for CD3, CD20, CD23, CD1O, KI67 CYCLIN D1 were performed on formalin-fixed, paraffin-embedded tissue sections of either bone marrow aspirate or core biopsy tissue sections in all 16 cases. Results There were 11 men and 5 women with a median age of 68 years (range, 40–74 years). Physical examination revealed splenomegaly in 15 out of 16 patients. Lymphadenopathy involving multiple sites was present in 10 patients. Conclusion MCL can exhibit a wide spectrum of morphologic findings. We suggest that cell size and chromatin characteristics are useful for dividing these cases into two groups: small cell and large/blastoid. The large/blastoid group predicts poorer prognosis and includes cases with large cells, many of which are nucleolated and resemble prolymphocytes, as well as blastoid cells that resemble lymphoblasts. In this study, a cut-off of at least 20% large/blastoid cells best predicted poorer survival.