Research progress on chemical structures and pharmacological effects of natural aucubin and its derivatives / 中草药

Aucubin, one of natural active constituents, is widely distributed in Chinese materia medica, such as Scrophularia ningpoensis, Eucommia ulmoides, Plantago depressa and so on, and its pharmacolagical activities have been paid more and more attention. Nevertheless, aucubin derivatives are rarely reported. In this review, the chemical constituents of aucubin derivatives mainly included 6-O-substituent type, 10-O-substituent type, 6,10-O-disubstituent type, 6′-O-substituent type and other types, meanwhile, their pharmacological activities, such as anti-oxidant, anti-inflammatory, antibacterial, neuroprotective and antitumor activities, were summarized in the recent 10 years.