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Scientific Journal of Al-Azhar Medical Faculty [Girls] [The]. 2003; 24 (1): 421-29
in English | IMEMR | ID: emr-64777

ABSTRACT

The present study was conducted on a group of seldom arteriopathic hyperlipidemic patients to investigate the availability of adhesion molecules measurement [ICAM-1, E-selectin] as well as vWF as markers of endothelial dysfunction, assisting in diagnosis or as indicators of disease progression. This study included 73 hyperlipidemic patients [43 males and 30 females] suffering from arterial occlusive disease. They were subdivided into group I [25 patients with mild hypercholesterolemia, group II [28 patients with severe hypercholesterolemia and group III [20 patients with hypercholesterolemia]. Control group consisted of 20 apparently healthy normolipidemic subjects, age and gender matching. Both patients and controls were subjected to the laboratory investigations [total cholesterol [TC], LDL-C, HDL-C, triglycerides, soluble intracellular adhesion molecule-1 [sICAM-1], soluble endothelial leukocyte adhesion molecule [sELAMs-sE-selectin] and von Willebrand factor [vWF]]. The level of sICAM-1, E-selectin and vWF were significantly higher in group with mild or severe hypercholesterolemia while the increase was nonsignificant in hypertriglyceridemia as regards ICAM-1 and E-selectin compared with the control group. The correlation between vWF and TC, LDL-C, sICAM or sE-selectin were significant, while sICAM showed significant correlation with only LDL-C. sE-selectin had no correlation with the lipid profile parameter. These results support the suggestion that vWF could serve as a marker of diagnosis, prognosis and follow-up of disease severity, while E-selectin is an indicator of early endothelial cell disturbance. sICAM could be also taken as an evidence of the atherosclerotic process. Hypertriglyceridemia seemed to be noninjurious to the endothelial wall


Subject(s)
Humans , Male , Female , Intercellular Adhesion Molecule-1 , von Willebrand Factor , Cholesterol , Lipoproteins, HDL , Triglycerides , Lipoproteins, LDL , Endothelium, Vascular , Risk Factors , Arteriosclerosis
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