Prothrombin fragment 1 - 2 as a marker of throm bosis risk in hemodialysis patients

Plasma levels of prothrombin fragment 12 [PF 1.2] were measured in 15 young patients on hemodialysis. PF 1.2 was significantly higher in the hemodialysis population compared to age and sex matched controls denoting increased intravascular thrombin generation in this patient group. The observed increase in PF 1.2 implies early activation of the coagulation system in end stage renal disease before the development of clinically significant vascular disease