ABSTRACT
Background: H. pylori has been recognized as a public health problem worldwide affecting approximately 50% of the world population and more prevalent in developing than the developed countries. It is a common infection in diabetic patients
Aim of the work: The study designed to study the prevalence of H. pylori infection in diabetic patients in comparison with non diabetic patients and the response to treatment ofH. pylori in both groups
Methods: WO patients were enrolled in the study. They were classified into 2 groups: Group [I] 50 patients complaining of dyspepsia with DM, and group [2] 50 non-diabetic patients complaining of dyspepsia. Serum H.pylori IgG antibodies and stools H.pylori antigen were determined for all patients by Gen Way H. pylori IgG ELISA and OneSite H pylori rapid test respectively
Results: H. Pylori stools Ag was positive in 58% of diabetics and 40% of non diabetics with no significant difference [P value 0.085]. Serum H.pylori Ig G were significantly positive in diabetes [52%] compared to non diabetic patients [32%]; P value 0.05. HE Ale was significantly higher in diabetics positive H.pylori cases compared to diabetics negative for H.pylori. Change in the HBAlc blood level before and after H.pylori treatment was highly significant in diabetic cases [P value <0.001]
H.pylori was more resistant to treatment in diabetic patients compared to non diabetics
Conclusion: No significant difference between both diabetics and non diabetics regarding prevalence of H pylori infection. Type 2 diabetic patients showed a significantly lower eradication rate than non diabetic patients. Successful eradication of H pylori infection significant I improve HBAlc