Pulmonary function tests in healthy male Punjabi children [10-19 years of age]

We performed spirometry on 177 male healthy children from Patiala, North India between 10 to 19 years age. The best fit regression equations for different functions were determined for each parameter. A linear relationship of lung function was observed with age, height, weight and BSA. Our results have been higher than the South Indian studies but closer to other North Indian studies. Similar comparison with western studies reveals that their subjects have higher lung function values than our subjects. It is clear that grossly erroneous conclusions may be reached unless prediction equations for lung function tests for a given ethnic group are derived from studies upon the same ethnic group.

Hypocholesterolemic response to angiotensin II in dogs.

Intravenous administration of angiotensin II caused a significant decrease in blood choelsterol level in dogs. This hypocholesterolaemic response, also obtained in spinal vagotomized and adrenalectomized dogs, indicates that central nervous system and adrenals have no role in angiotension II induced hypocholesterolemic effect. In hepatectomized dogs in which both vagi were intact intravenously administered angiotensin did not cause any significant decrease in blood choelsterol level, suggesting that angiotensin exerts its effect by inhibiting the synthesis or preventing the release of cholesterol from the liver.