ABSTRACT
Introduction: Coronary heart disease (CHD) is a major causeof mortality and morbidity all over the world. This study wasundertaken to assess the resolution of ST segment at 90 min ofthrombolysis in STsegment elevation myocardial infarction asa predictor of short term outcome in terms of adverse eventsand mortality during hospital stay.Material and methods: A total of 100 patients with firstepisode of ST elevation myocardial infarction without anyconventional contraindication for thrombolysis were takenfor the study. % of ST segment resolution after 90 minof thrombolysis was calculated and correlation with vitalparameters like Killip class, ejection fraction, incidence ofarrhythmias, prognosis in the patients with acute MyocardialInfarction.Results: Out of 100 patients who were thrombolysed, 30%had failed thrombolysis. Patient who presented within 6hours of chest pain had 7.7% failed thrombolysis which wassignificantly lower than patients who presented >6 hrs ofchest pain with 44.5% failure rate, p value 0.0002. Failure ofthrombolysis was higher in Diabetic patient (p value= 0.02)and hypertensive patient (p value= <0.0001). Risk factorslike diabetes, hypertension significantly affect the outcomeof thrombolysis. Mortality was seen in 10 patients, 80% hadfailed thrombolysis, p value< 0.001.Conclusion: Patients with No resolution of ST segment at 90min of thrombolysis had frequent adverse events and highermortality when compared to patients with partial and completeST segment resolution.