ABSTRACT
The data of well-differentiated thyroid carcinoma in 677 patients who have been followed up from 1979 to 1998 were analyzed at Nuclear Medicine Section, Siriraj Hospital. The results revealed that the sex ratio of female: male was 2.96:1, and the age ranged between 9 and 96 years with the mean + SD of 45.8 + 16.6 years. The peak incidence of female patients occurred chiefly in the middle age (31-40 years), while the majority of male patients occurred predominantly in late middle age and in the elderly (51-61 years). The patients with papillary, follicular and mixed papillary-follicular carcinomas were 49.0%, 40.0% and 11.0%, respectively. These data also indicated that 8.0% of thyroglobulin antibodies and 5.3% of microsomal antibodies by haemagglutination method were detected in the sera of these patients. Moreover, the follow-up times of the patients with treated differentiated thyroid carcinomas at 1-11 months, 1-5 years, 6-10 years, 11-15 years and over 16 years were found to be 13.1%, 62.3%, 14.8%, 7.0% and 2.8%, respectively.
ABSTRACT
Radionuclide breast imaging, also called scintimammography (SMM) was performed using Tc-99m MIBI in 37 patients with palpable breast masses. A total of 38 lesions were analyzed. Twenty cases subsequently underwent modified radical mastectomy while the remainder underwent only biopsy or fine needle aspiration for histologic proof. The average size of the masses were 3.03+1.61 x 4.10+2.89 cm in diameter. Twenty-six lesions were malignant and 12 were benign; 23 malignancies showed positive MIBI uptake but three did not. The false negative cases were all invasive ductal carcinomas. Nine benign lesions were true negatives and three were false positives. They were mastitis, foreign-body granuloma and fat necrosis which chronic inflammation. Of 14 cases which histologically proved to have axillary node metastasis, only 7 revealed positive MIBI uptake. The sensitivity and spectively. However, in the detection of axillary node metastasis, the sensitivity was only 50 percent. Thus, Tc-99m MIBI SMM is helpful in the diagnosis of routine mammography. However, the imaging is not accurate enough for the detection of axillary node metastasis. In addition, Tc-99m MIBUI SMM also plays an important role in terms of prognosis and therapeutic planning in patients with breast cancer.