ABSTRACT
Central Giant Cell Granuloma [CGCG] is a benign tumor of jaw. As compared to males, females are more commonly affected. Mandible is the common site of occurrence. Aneurysmal bone cysts [ABCs] are cystic lesions which are expansile osteolytic blood-filled lesions. These are commonly seen in the mandible, and they also show gender-predilection towards females. Concurrence of both the lesions is rarely reported. The treatment of both CGCG and ABC depends upon the extent of the lesions as well as on their nature. Due to aggressive nature of the lesions, these usually cause disfigurement of the patients' face. Wide excision is the treatment modality for aggressive lesions to avoid recurrence. We present a case of 28-year male who showed CGCG along with ABC in the same lesion, a rare concurrence
ABSTRACT
Objective: To assess the prognostic potential for N-cadherin in oral squamous cell carcinoma and oral epithelial dysplasia
Study Design: A cross-sectional study, analytical study
Place and Duration of Study: Maharishi Markandeshwar College of Dental Science Research [MMCDSR], Ambala, India, from 2011 to 2014
Methodology: Immunohistochemistry was used to observe the N-cadherin expression in 100 cases having epithelium with normal oral mucosa, oral epithelial dysplastic lesions and oral squamous cell carcinoma [OSCC]. For statistical significance, SPSS 13.0 was used to calculate the data by Mann-Whitney and Kruskal-Wallis tests
Results: In OSCC, N-cadherin expression was more evident than in oral epithelial dysplasia followed by the normal oral epithelium that did not show any dysplastic changes [p=0.001]. Conversely, N-cadherin expression was not significant among the histological grade of OSCC
Conclusion: N-cadherin can be used as a potential biomarker for early diagnosis of OSCC. However, the N-cadherin expression did not show any correlation with the histological grade of OSCC
ABSTRACT
Angiomyxolipoma is a rare histological variant of lipoma, characterized by proliferation of adipose tissue associated with a variable amount of myxoid stroma with numerous thick- and thin-walled blood vessels. An exhaustive literature review could reveal only 12 cases of angiomyxolipoma affecting subcutaneous tissue, subungual area and spermatic cord. In oral cavity, only 2 cases of angiomyxolipoma have been reported to date, one case in the buccal mucosa and one case in the floor of the mouth. Hence, this is only the third case of angiomyxolipoma affecting oral cavity and the first case of angiomyxolipoma of the tongue. We report a case of a 51-year male presenting with a swelling on the right lateral border of the tongue. The lesion was excised and microscopical examination confirmed the diagnosis of angiomyxolipoma
Subject(s)
Humans , Male , Middle Aged , Angiolipoma , Myxoma , Tongue Neoplasms , TongueABSTRACT
An entity of bizarre plasma cells has been observed, containing spherical inclusions of immunoglobulins within the cytoplasm
These cells are termed as Mott cells and are believed to occur commonly in cases of chronic inflammation. Until now, they were reported to occur in systemic diseases, various hematolymphoid malignancies and in some syndromes; but their occurrence in chronic periapical infections of the oral cavity, given the paucity of available literature, raises questions about their obscure nature. In the present case report, a 24-year male presented with a draining sinus and periapical lesion involving the maxillary right incisors. After clinical and radiographic examination, an excisional biopsy sample of the periapical lesion was obtained. Histopathological examination revealed multiple bizarre Mott cells in the connective tissue stroma. The significance, nature or fate of these Mott cells is still unknown
Frequently overlooked or a chance occurrence, the presence of these multiple Mott cells in chronic inflammatory lesions of the oral cavity could be of some significance and demand increased awareness and further research