[Evaluation of the value of urinary calcium to creatinine ratio for predicting pre-eclampsia]

Pre-eclampsia is one of the most serious complications in pregnancy and is one of the major causes of maternal death during pregnancy. Therefore, its prediction has special importance and many studies have been performed on different materials, which may be useful for its prediction. The purpose of the present study was to evaluate the urine calcium to creatinine ratio for prediction of pre-eclampsia. A prospective cohort study was performed on 150 pregnant women who were 15-35 years old. A single urine sample was obtained at 20-24 weeks of gestation for measurement of urinary calcium and calcium to creatinine ratio. The women were followed till delivery and this ratio was compared between the women with and without pre-eclampsia. Statistical analysis was performed with t-test, Roc Curve and SPSS version 16. p value < 0.05 was considered as statistically significant. Mean urinary calcium of pre-eclamptic women was significantly lower than normotensive women [179 +/- 35 mg/dl vs 272 +/- 59 mg/dl, p<0.001].Mean calcium to creatinine ratio was significantly lower in pre-eclamptic women [0.07 +/- 0.007 vs 0.16 +/- 0.006, p<0.001].The optimal cut off point for calcium to creatinine ratio was calculated 0.071 with a sensitivity of 77% and specificity of 78%. Urinary calcium and calcium to creatinine ratio are lower in pre-eclamptic women and may be used as a screening test for the prediction of pre-eclampsia

[Obstetric outcomes in pregnant women with and without uterine leiomyoma]

Background: Uterine leiomyomas [myomas] are the most frequent benign uterine tumors, several studies have suggested that each leiomyoma arises from a single neoplastic cell within the smooth muscle of myometrium and in 4 percent of pregnant women, sonographically detectable myomas are present

Methods and Materials: A cohort study done in years of 1385-86 to compare obstetric outcomes between normal pregnant and pregnant women with myomas, 87 pregnant with myoma and 375 normal pregnant selected for pre, intra and post partum complications

Results: Myoma in pregnancy is a risk factor for first trimester bleeding, spontaneous first trimester abortion, placenta previa, noncephalic presentation, post partum hemorrhage and cesarean delivery but frequency of preterm labor, premature rupture of membrane, placental abruption and intra uterine growth restriction were not different between group with myoma and control group. Furthermore the rate of post partum hemorrhage in group with myoma larger than 5cm in diameter was greater than in group with myoma 5cm or smaller in diameter [P=0.02]. After multiple logistic regression analysis, advanced maternal age, nulliparity were independently associated with presence of myoma in pregnancy

Conclusion: Presence of myoma documented by gestational sonography is associated with high risk pregnancies which necessitate patient education and labor staff preparation for intra and post partum probable complications controlling