ABSTRACT
Objective To study the effects of tigecycline on immune function in patients with complicated intra-abdominal infections (cIAI). Methods A total of 24 cIAI patients received treatment of tigecycline, and then the effects of tigecycline on level of peripheral blood monouclear cells (PBMC) proliferation, concentration of inflammatory cytokines, and expression of CD3, CD4 and CD8 were investigated. Results The total effective rates of tigecycline were 70. 8％. Tigecycline treatment significantly reduced proliferative level of PBMC, decreased the levels of interleukin-1β (IL-1β), IL-6 and IL-8 in supernatants of PBMC cultures as well as serum. Moreover, tigecycline therapy significantly up-regulated the percentage of CD3 + and CD4 +, increased the ratio of CD4+ / CD8 +, and down-regulated percentage of CD8 + in peripheral blood. Conclusion Tigecycline could regulate immune function in cIAI patients.