Tumor filoides de la mama / Phyllodes tumor of the breast

Introduction: The phyllodes tumor (PT) of the breast is a rare disease of unknown origin. Despite its classification into benign, borderline and malignant, their behavior tends to be uncertain. Because of this, treatment remains controversial. Objective: To describe the management of the FT in breast pathology unit of our hospital and their outcomes. Material and Methods: We retrospectively reviewed the files of the patients with PT, operated in our hospital between 2001 and 2008. We analyzed the clinical characteristics, diagnostic studies, treatment and outcomes. Results: During this period 12 patients were operated. The ave-rage age was 42 +/- 15.2 years (16-64) and usually the form of presentation was painless palpable nodule. Both mammography and ultrasound were unable to suggest the diagnosis. Eight patients had core biopsy, which revealed the diagnosis of PT in 5, while in the other 3 was fibroadenoma. All patients underwent a partial mastectomy. The biopsy showed six benign, two borderline and two malignant PT. The latter two patients received adjuvant radiotherapy. At the end of this study, 2 patients had relapsed at 12 and 30 months (borderline and benign, respectively). There were no cases of lymphatic or distant metastases. Conclusions: The PT has a low frequency of presentation and preoperative diagnosis is difficult, so we recommend a core biopsy, but it can confuse with fibroadenoma. The management with partial mastectomy and negative borders had a recurrence rate of 18 percent in this series.

Introducción: El tumor filoides (TF) de la mama es una patología poco frecuente y origen desconocido. A pesar de su clasificación en benignos, borderline y malignos, su comportamiento tiende a ser incierto. Debido a esto su tratamiento sigue siendo controversial. Objetivo: Describir el manejo del TF en la unidad de patología mamaria del Hospital San José y sus resultados. Material y Método: Se revisaron las fichas de las pacientes con diagnóstico de TF, operadas en nuestro hospital entre los años 2001 y 2009. Se analizaron las características clínicas, estudios diagnósticos, tratamiento y resultados. Resultados: Durante este período se operaron 12 pacientes. El promedio de edad fue 42 +/- 15,2 años (16-64) y habitualmente la forma de presentación fue nodulo palpable indoloro. Tanto la mamografía como la ecografía fueron incapaces de sugerir el diagnóstico. Ocho pacientes tenían biopsia core, la cual evidenció el diagnóstico de TF en 5, mientras que en las otras 3 resultó fibroadenoma. Todas las pacientes fueron sometidas a mastectomía parcial. En seis pacientes resultó ser TF benigno, en dos borderline y en dos maligno. Estas últimas dos pacientes recibieron radioterapia adyuvante. Al término de este estudio 2 pacientes habían recidivado a los 12 y 30 meses (borderline y benigno respectivamente). No hubo casos de metástasis linfáticas ni a distancia. Conclusiones: El TF tiene una baja frecuencia de presentación, su diagnóstico preoperatorio es difícil recomendándose la biopsia core, sin embargo, suele confundirse con el fibroadenoma. El manejo con mastectomía parcial y bordes negativos tuvo una recidiva del 18 por ciento en esta serie.

Carcinoma medular de tiroides: experiencia de 20 años / Medullary thyroid carcinoma: 20 years experience

Background: Medullary thyroid carcinoma (MTC) is a rare malignant tumor that arise from C cells. Surgical treatment and its results are controversial, so we decided to study it. Aim: To describe clinically MTC, treatment and outcomes in the long term. Material and Method: We retrospectively reviewed medical records of patients with MTC operated in our hospital between the years 1987 and 2007. We analyzed the cli-nical characteristics, treatment, morbidity and long-term follow up. Results: There were 24 patients operated with a mean age of 46.1 +/- 16.6 years. The main form of presentation was painless increased cervical volume (56.2 percent). In 15 percent this pathology was part of a MEN 2b. All of them have had a total thyroidectomy, which was extended in 50 percent of cases. The 35.2 percent were multifocal, 29.4 percent bilateral and 62.5 percent had metastatic lymph node involvement. Five patients remained higher calcitonin levéis in the postoperative period and 9 patients recurred clinically on average 4.5 years after surgery. The presence of persistent disease was significantly associated with hereditary MTC (p = 0.0088) and the clinical recurrence was significantly determined by the presence of not expanded total thyroidectomy (p = 0.0196). The probability of surviving more than 19 years was 66.6 percent (95 percent CI = 0.24 to 0.89). Conclusions: The MTC is a rare tumour and treatment of choice is surgery. The persistent disease is associated with hereditary MTC form, and the clinical recurrence is associated with not expanded total thyroidectomy. We recommend total thyroidectomy with central voiding and radical modified jugular dissection.

Antecedentes: El carcinoma medular de tiroides (CMT) es un tumor maligno poco frecuente, originado a partir de las células C. Su tratamiento quirúrgico y resultados son controvertidos, por lo que hemos decidido estudiarlo. Objetivo: Describir clínicamente el CMT, tratamiento y resultados a largo plazo. Material y método: Se revisaron retrospectivamente las fichas clínicas de pacientes con CMT operados en nuestro hospital entre 1987 y el 2007. Se analizaron las características clínicas, tratamiento, morbilidad y seguimiento a largo plazo. Resultados: Se operaron 24 pacientes, cuya edad media fue 46,1 +/- 16,6 años. La principal forma de presentación fue aumento de volumen cervical (56,2 por ciento). Un 15 por ciento formaba parte de una NEM 2b. A todos se les realizó una tiroidectomía total, ampliada en el 50 por ciento de los casos. El 35,2 por ciento eran multifocales, el 29,4 por ciento bilaterales y el 62,5 por ciento tenía metástasis ganglionar. Cinco pacientes mantuvieron niveles de calcitonina elevados en el postoperatorio y nueve pacientes recurrieron clínicamente, en promedio, a los 4,5 años. La enfermedad persistente se asoció significativamente con CMT hereditario (p = 0,0088) y la recurrencia clínica a tiroidectomía total no ampliada (p = 0,0196). La probabilidad de sobrevivir más de 19 años fue 66,6 por ciento (IC 95 por ciento = 0,24 a 0,89). Conclusiones: EL CMT es un tumor raro cuyo tratamiento de elección es la cirugía. La persistencia de enfermedad se asocia con la forma hereditaria, y la recurrencia clínica con la tiroidectomía total no ampliada, lo que nos hace recomendar una tiroidectomía total asociada a vaciamiento central y disección yugular radical modificada.

Alteraciones del metabolismo del fierro post by pass gástrico / Metabolic iron disorders post gastric by pass

A complication of bariatric surgery and especially gastric bypass are nutritional deficiencies that occur in the long term, being very important iron deficiency and anemia. Several mechanisms influence this, highlighting the exclusion of the duodenum and part of jejunum. Is in these places which have been described the presence of the iron transporter, which is over expressed in situations of iron deficiency. Special adaptation mechanisms may explain the maintenance of iron homeostasis in these patients. Associated with this, they require a specific nutritional management including diet and special supplements, however, despite this there is a proportion of patients who will develop the deficit and in some cases even become a major problem. Today we know several pathways, proteins and transporters involved in iron metabolism, mainly at the level of absorption, but little is known about the changes that occur at this level in people undergoing deficit, such as patients undergoing gastric bypass and the changes that occur here to optimize it metabolism. Here you will see a review of the iron metabolism and then a description of the changes that occur in its physiology following a gastric bypass.

Tumor fibromixoide osificante simulando un cáncer anaplásico de tiroides: reporte de un caso / Ossifying fibromyxoid tumor of the neck: case report

El tumor fibromixoide osificante corresponde a una neoplasia infrecuente, de comportamiento benigno pero que presenta recurrencia en un tercio de los casos, comportándose como un sarcoma de bajo grado. Se reporta el caso de una paciente operada de tiroides en dos oportunidades en 9 años, cuyo diagnóstico final fue tumor fibromixoide osificante.

Ossifying fibromyxoid tumor of soft parts in an uncommon tumor with a benign behavior but with a tendency to relapse. We report a 76 years old female presenting with a growing mass located in the anterior portion of the neck that was excised. The pathological study disclosed an anaplastic thyroid cancer. The patient received chemotherapy and was lost from follow up. Nine years later, she presented with progressive dysphagia. A neck CT scan showed a mass in the left thyroid base that completely included the cervical esophagus. The patient was operated and the mass was excised. The pathological diagnosis disclosed an ossifying fibromyxoid tumor.