ABSTRACT
Justification: Data generated after the first wave has revealed that some children with coronavirus 19 (COVID-19) can become seriously ill. Multi-inflammatory syndrome in children (MIS-C) and long COVID cause significant morbidity in children. Prolonged school closures and quarantine have played havoc with the psychosocial health of children. Many countries in the world have issued emergency use authorisation (EUA) of selected COVID-19 vaccines for use in children. In India, a Subject Expert Committee (SEC) has recommended the use of Covaxin (Bharat Biotech) for children from the ages of 2-18 years. The recommendation has been given to the Drugs Controller General of India (DCGI) for final approval. Objective: To provide an evidence-based document to guide the pediatricians on the recommendation to administer COVID vaccines to children, as and when they are available for use. Process: Formulation of key questions was done by the committee, followed by review of literature on epidemiology and burden of COVID-19 in children, review of the studies on COVID vaccines in children, and the IAP stand on COVID-19 vaccination in children. The available data was discussed in the ACVIP focused WhatsApp group followed by an online meeting on 24 October, 2021, wherein the document was discussed in detail and finalized. Recommendations: The IAP supports the Government of India’s decision to extend the COVID-19 vaccination program to children between 2-18 years of age. Children with high-risk conditions may be immunized on a priority basis. The IAP and its members should be a partner with the Government of India, in the implementation of this program and the surveillance that is necessary following the roll-out.
ABSTRACT
AIMS OF STUDY: To study effect of yoga on the physiological, psychological well being, psychomotor parameter and modifying cardiovascular risk factors in mild to moderate hypertensive patients. METHODS: Twenty patients (16 males, 4 females) in the age group of 35 to 55 years with mild to moderate essential hypertension underwent yogic practices daily for one hour for three months. Biochemical, physiological and psychological parameters were studied prior and following period of three months of yoga practices, biochemical parameters included, blood glucose, lipid profile, catecholmines, MDA, Vit. C cholinesterase and urinary VMA. Psychological evaluation was done by using personal orientation inventory and subjective well being. RESULTS: Results showed decrease in blood pressure and drug score modifying risk factors, i.e. blood glucose, cholesterol and triglycerides decreased overall improvement in subjective well being and quality of life. There was decrease in VMA catecholamine, and decrease MDA level suggestive decrease sympathetic activity and oxidant stress. CONCLUSION: Yoga can play an important role in risk modification for cardiovascular diseases in mild to moderate hypertension.
Subject(s)
Adaptation, Physiological , Adult , Blood Glucose/metabolism , Cholesterol/blood , Female , Humans , Hypertension/blood , Male , Middle Aged , Psychophysiology , Risk Factors , Severity of Illness Index , YogaSubject(s)
Adolescent , Bronchoscopy , Female , Humans , Neurilemmoma/diagnosis , Tomography, X-Ray Computed , Trachea/pathology , Tracheal Neoplasms/diagnosisABSTRACT
The behavioural and electroencephalographic responses resulting from stimulation of a specific area in the nucleus medialis dorsalis (nMD) of unanaesthetized juvenile Rhesus monkeys is described. A behavioural arrest reaction, lack of awareness and motor inhibition with concomitant 2 1/2 to 3Hz spike and wave EEG afterdischarge patterns were obtained by stimulation of the nMD in monkeys with bilaterally symmetrical aluminium hydroxide Al (OH)3 lesions in anterior premotor cortical areas.
Subject(s)
Aluminum Hydroxide/toxicity , Animals , Autonomic Nervous System/physiology , Electric Stimulation , Electrocardiography , Electroencephalography , Electrooculography , Macaca mulatta , Male , Motor Activity/drug effects , Thalamic Nuclei/physiology , Thalamus/physiologyABSTRACT
A bilaterally synchronous 3/sec spike and wave pattern in the EEG can be obtained during stimulation of the nucleus medialis dorsalis (nMD) and nucleus paracentralis (nPC) of the thalamus, in lightly anaesthetized juvenile monkeys. The spike and wave EEG patterns have a frequency of 2 1/2 to 3Hz and occur during low frequency stimulation, without continuing into the post-stimulatory phase. Stimulation of the mesencephalic reticular formation (MRF) at higher voltages inhibits the thalamic-induced spike and wave response. This finding has heuristic significance, as activating stimuli arrest the wave and spike EEG pattern of human absence (petit mal epilepsy) seizures. The study also demonstrates the morphological similarity of the 3/sec spike and wave thalamic induced response in experimental and clinical absence states as well as similarities in their alterations with different levels of activation.