ABSTRACT
Malondialdehydemia (MDA),, measurements of heart and liver tissue damage (TDU), plasma activity of heart alfa - hydroxybutyrate dehydrogenase (LDH1) and liver lactate dehydrogenase (LDH5) were determined in non-infected mice and in mice infected with 10*5 T. cruzi, Y strain, bloodstream trypomastigotes. All the parameters measured were increased (P < 0,01) in infected mice 8 days after intraperitoneal inoculation. The results indicate that plasma MDA levels can serve as a useful indicator of the systemic tissue injury found in chagas' disease
Subject(s)
Mice , Animals , Male , Chagas Disease/blood , Liver/enzymology , Malondialdehyde/blood , Myocardium/enzymology , Malondialdehyde/blood , Chagas Cardiomyopathy/blood , Trypanosoma cruzi/pathogenicityABSTRACT
Evolution of the acute phase of experimetnal Chagas' disease was correlated with tissue damage and plasma levels of malondialdehyde. heart lesions were quantified by the Tissue Damage Unit (TDU) and malondialdehydemia (MDA) by the colorimetric determination of malondialdehyde. the binary correlations were: C(X,Y) =0.965 (P < 0.001); C(y,Z) =0.784 (P < 0.01); and C(X,Z) =0.824 (P < 0.01), where X = days of infection, Y = TDU means and Z = MDA means. These results show a positive correlation between the duration of the acute phase of experimental Cchagas' disease and TDU, and between the durtion and MDA. The methods for measuring tissue damage and MDA are shown to be simple and adequate for monitoring tissue aggression in the protozoosis studied
Subject(s)
Mice , Animals , Male , Chagas Disease/pathology , Malonates/blood , Malondialdehyde/blood , Chagas Cardiomyopathy/pathology , Trypanosoma cruzi , Mice, Inbred Strains , Inflammation/pathologyABSTRACT
Parasitemia and malondialdehydemia were compared during the acute phase of the infection caused by the CL and Y strains of T. cruzi. Parasitemia was measured by counting blood trypamastigote forms, and malondialdehydemia by a colorimetric method. The duration of the acute phase of Chagas' disease was correlated with malondialdehydemia in both CL and y strains. The correlations between parasitemia and duration of the acute phase, as well as between parasitemia and malondialdehydemia, were significant only in the group infected with the CL strain. These data suggest that malondialdehydemia may be an adequate parameter for evaluating and monitoring the acute phase in experimental Chagas' disease
Subject(s)
Mice , Animals , Male , Chagas Disease/blood , Malondialdehyde/blood , Trypanosoma cruzi/isolation & purification , Acute Disease , Mice, Inbred Strains , Chagas Disease/parasitologyABSTRACT
Os autores analisaram 195 pacientes com diagnostico de carcinoma do corpo uterino tratadas no Instituto de Ginecologia da Universidade Federal do Rio de Janeiro num periodo de 44 anos. Eles verificaram a correlacao entre algumas condicoes patologicas como antecessores da doenca. Sao feitas consideracoes sobre o futuro dos diagnosticos do potencial biologico dos chamados precursores