ABSTRACT
To determine the frequency of underlying causes of pyrexia of unknown origin on bone marrow examination. Descriptive study. The study was carried out at Hematology department [pathology] of Army Medical College, National University of Sciences and Technology [NUST] and Military Hospital Rawalpindi [during the period of one year] from Jan 2012-Dec 2012. Total of 94 patients reporting with pyrexia of unknown origin at MH Rawalpindi underwent bone marrow examination. Bone marrow aspiration procedure was done from posterior superior iliac spine in patients older than one year while tibial tuberosity was used in patients less than one year of age. Lumbar puncture needle of 16 G was used for bone narrow aspiration and trephine biopsy was done by using 11 G trephine biopsy needle. In children, commonest causes observed were acute lymphoblastic leukaemia in 7 [23.3%], marked haemophagocytosis in 4 [13.3%] and visceral leishmaniasis in 4 [13.3%] patients. In adults, commonest causes included megaloblastic anaemia in 13 [20.3%], lymphoproliferative disorders in 8 [12.5%] and hypersplenism in 5 [7.8%] patients. This study concludes that causes of pyrexia of unknown origin vary with age of the patient. The most frequent causes of pyrexia of unknown origin observed in children were acute lymphoblastic leukaemia, marked haemophagocytosis, and visceral leishmaniasis where in adults main causes were megaloblastic anaemia, lymphoproliferative disorders and hypersplenism
ABSTRACT
To determine the frequency of different causes of pancytopenia on bone marrow examination. Descriptive study. The study was carried out at Haematology [pathology] department of Army Medical College, National University of Sciences and Technology [NUST] and Military Hospital Rawalpindi from Jan 2012- Dec 2012. Total 67 cases of pancytopenia were included in the study. Bone marrow aspiration was done using 16 GLP needle and biopsy was done by using 11 G Trephine biopsy needle. Out of 67 patients, [15%] were children and [52%] were adults. Among children leishmaniasis and hypersplenism were the most common causes [20%] of pancytopenia followed by acute leukemia [3.8%], aplastic anaemia [6.7%] and megaloblastic anaemia [6.7%]. Among adults megaloblastic anaemia was the most common cause [40.4%] followed by lymphoproliferative disorder [15.4%], hypersplenism [7.7%], aplastic anaemia megaloblastic anaemia, acute leukemia and myelodysplasia. Major causes of pancytopenia in children were leishmaniasis and hypersplenism where as in adults they were megaloblastic anaemia and lymphoproliferative disorders