ABSTRACT
This study examines the characteristics and agreement between different definitions of metabolic syndrome [MetS] and insulin resistance [IR]. A total of 347 non-diabetic individuals who were >/= 20 years of age were selected from the Tehran Lipid and Glucose Study [TLGS]. Subjects were categorized as having MetS by the Adult Treatment Panel III [ATP III] and the Joint Interim Statement [JIS]. IR was estimated by using the homeostasis model assessment [HOMA-IR]. According to ATP III and JIS criteria 38.9% and 38.2% of subjects had MetS respectively. The sensitivity of ATP III was 52.3% and specificity was 65%; for JIS the sensitivity was 52.3%, with a specificity of 66.5%. Kappa between ATP III or JIS and HOMA-IR was 0.14 and 0.16, respectively. Based on receiver operating characteristic [ROC] analysis, the use of waist circumference [WC] and fasting plasma glucose [FPG] for the diagnosis of IR in women showed a diagnostic accuracy equal to or instead of counting MetS components using modified ATP III or JIS. WC optimal cut points for prediction of IR were 93.5 cm for men and 92.5 cm for women. ATP III and JIS definitions have low sensitivities and specificities for detecting IR. There is poor agreement between these criteria and IR
Subject(s)
Humans , Male , Female , Insulin Resistance , Waist Circumference , Body Mass IndexABSTRACT
Background: diabetes type 1 is an autoimmune disease that is associated with other autoimmune disorders like Hashimoto thyroiditis. The purpose of this study was to determine the prevalence of autoimmune thyroid disease [ATD] in type 1 diabetic patients in the south of Iran [Bandar Abbas]
Methods: a cross-sectional study, was conducted 48 type 1 diabetics and 41 age and sex matched healthy controls were evaluated for the presence of ATD. Blood sample were collected from all of the subjects for the measurement of thyroid autoantobodies [anti thyroid peroxidase [anti-TPO] and anti thyroglobulin [anti-TG]], T3, T4, TSH, RT3U and HbA1c
Results: prevalence of positive anti-TPO and anti-TG was 29 % and 29% respectively in diabetic patients and 2% and 7% respectively in control group [P<0.05]. The prevalence of ATD [positive anti TPO or anti TG] in diabetic patients and control subjects was 35% and 7% respectively [P<0.05]. The prevalence of positive anti TPO and anti TG was higher in girls. There was no association between the prevalence of positive autoantibody and duration or age of onset of diabetes. 17.6% of diabetic patients with positive autoantibody had thyroid dysfunction [subclinical hypothyroidism and hyperthyroidism]
Conclusion: regarding high prevalence of ATD in type 1 diabetic patients in Bandar Abbas [approximately 1 out of 3 patients], screening for ATD and thyroid dysfunction is recommended for all type 1 diabetic patiens and in those with positive autoantibody consecutively