ABSTRACT
Aim: The aim of this study was to design multi-walled carbon nanotubes [MWCNTs] loaded with paclitaxel [PTX] anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer
Background: Carbon nanotubes [CNTs] represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading
Patients and Methods: In this study, multi-walled carbon nanotubes [MWCNTs] pre-functionalized covalently with a paclitaxel [PTX] as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope [SEM], particle size analyzer and cellular analyses
Results: A well conjugated of anti-cancer drug on the carbon nanotube surfaces was shown. This study demonstrates that the MWCN-PTX complex is a potentially useful system for delivery of anti-cancer drugs. The flow cytometry, CFU and MTT assay results have disclosed that MWCNT/PTXs might promote apoptosis in MKN-45 gastric adenocarcinoma cell line
Conclusion: According to results, our simple method can be designed a candidate material for chemotherapy. It has presented a few bio-related applications including, their successful use as a nano-carriers for drug transport