ABSTRACT
RATIONALE@#Breast cancer is the most prevalent cancer in the world. It is usually diagnosed in women 50 years old and older, but is also found in younger women. Its occurrence in young women led to questions with regards issues on its tumor biology, survival and fertility. There is insufficient local data to formulate treatment options relevant to this age group. This study reviews the data on breast cancer in young female patients seen in a tertiary institution.@*METHODS@#This is a descriptive study involving a review of medical records of young female breast cancer patients (<35 years of age), seen at the Philippine General Hospital - Breast Care Center from January 2008 to December 2017. @*RESULTS@#A total of 119 patients were included in the study. Of these young female patients, 29.4% presented with locally advanced disease (Stage IIIB) correlating with a high number of patients who underwent neoadjuvant chemotherapy (38.7%) and modified radical mastectomies with primary closure (62.18%). @*CONCLUSION@#Breast cancer in young females should be aggressively investigated as it commonly presents in an advanced stage.
ABSTRACT
RATIONALE/OBJECTIVE@#Breast cancer among males is often diagnosed at a later age and at an advanced stage. The study aimed to present the epidemiology, associated risk factors, clinical and pathological characteristics, treatment patterns and outcomes of male breast cancer patients treated at the Philippine General Hospital from January 2008- December 2017. Information from this study can provide for better understanding of the disease and basis for creating guidelines toward better outcomes. @*METHODS@#Retrospective study of medical records involving male breast cancer patients who underwent surgery and treatment at the Philippine General Hospital from January 2008- December 2017.@*RESULTS@#Male breast cancer accounted for 15 (0.26%) of 5,777 resected breast specimens for breast cancer patients with a 1:384 male to female ratio. The mean age of presentation was 60 years. The most common presentation was a retro-areolar mass, with 33% of patients presenting post-excision. Sixty-seven percent were at Stage II and 20% at Stage III. About 94% of patients have invasive ductal carcinoma, while the only other histology is papillary carcinoma at 13%. Majority of those tested were both estrogen receptor and progesterone receptor (ER/PR) positive (33% versus 1 %), and Her2neu negative. All patients underwent modified radical mastectomy. Only two patients were documented to have received adjuvant chemotherapy while one patient received neoadjuvant chemotherapy.@*CONCLUSION@#Breast cancer remains to be a rare disease among males, is often diagnosed at a later age and at an advanced stage. Because of its rarity, awareness is necessary not only in the community but also among healthcare providers to identify and treat the problem earlier. Further investigation and prospective studies are recommended.