ABSTRACT
Background: The aim of the study was to observe common adverse drug reactions in treatment of gastro intestinal and respiratory tract infections in a tertiary care hospitals.Methods: A prospective observational study was conducted by Departments of Pharmacology for a period of one year from prescriptions and case sheets of medical record section. Adverse drug reaction reporting forms and alert cards were used for reporting.Results: The drugs most commonly used for gastrointestinal tract and respiratory diseases are tablets norflox 400 mg, norflox-tz, taxim 200 mg, IV amikacin and iv amoxicillin (500 mg) and clavulanic acid (125 mg) combination. Systems affected by use of above drugs were skin and gastrointestinal tract. Urticaria on skin, abdominal pain, itching in genital area, ulcer on oral mucosa are the common adverse drug reactions observed.Conclusions: Drugs used for common gastrointestinal tract and respiratory tract infections alert cards should be issued to patients when prescribing and adverse drug reactions should be reported to higher centres. Brand names causing adverse reactions should be monitored regularly and their further usage should be based on signals from other centres. All tertiary care hospitals should have antimicrobial guidelines policy to reduce adverse drug reactions.
ABSTRACT
Background: The objective of this study was to evaluate efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced swiss albino mice.Methods: Study was placebo controlled, randomized laboratory based comparative study with prior permission of Institutional animal ethical committee. Experimental animals were divided in to seven groups as control (distilled water 10ml/kg), standard Fluoxetine two doses (10mg/kg and 20mg/kg) , test drug ondansetron three doses (0.5mg/kg, 1mg/kg and 2mg/kg) and combinations of test and standard (0.5mg/kg + 10mg/kg).The drugs were administered intraperitonium and antidepressant activity was recorded using physically induced depression models tail suspension test and despair swim test.Results: Ondansetron treated albino mice groups with dose dependent increase of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg showed significant decrease in antidepressant activity and increase in catalepsy score when compared with fluoxetine 10mg/kg and 20mg/kg. Combination doses showed stastically significant antidepressant activity.Conclusions: The present study indicates ondansetron showed promising antidepressant activity due to its ability to modulate serotonergic system and has proved to be safe in the dose range of 0.5mg/kg, 1mg/kg and 2mg/kg in mice.