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1.
Bulletin of Pharmaceutical Sciences-Assiut University. 2009; 32 (2): 339-347
in English | IMEMR | ID: emr-136277

ABSTRACT

Two simple and sensitive spectrophotometric methods were developed for the determinagion of paracetamol [I] and ascorbic acid [II] in pharmaceutical binary mixture. The first method depends on the use of the first-derivative spectrophotometric technique for the slinultaneons determination of components of the mixture. The second method depends on the reaction of the studied drugs with 5-diazo-1, 2, 4-triazol-3-carboxylic acid [DTCA] reagent to give colored products measured at 480 nm and 580 nm for [I] and [II] respectively. All variables affecting reaction conditions were optimized The proposed methods were successfully applied for the analysis of the studied drugs in their pare and commercial dosage forms and are in good agreement with those obtained from the reported methods. No significant difference in the acuracy and precision as revealed by the accepted values of t- and F-tests, respectively. Molar ratios of the drugs with the colorimetric reagent [DTCA] were determined and the reaction mechanisms were suggested

2.
Bulletin of Pharmaceutical Sciences-Assiut University. 2008; 31: 183-195
in English | IMEMR | ID: emr-86042

ABSTRACT

Simple and very sensitive spectrofluorimetric methods were developed for determination of adrenaline [I] -procaine hydrochloride [II] mixture and salbutamol sulfate [III] - guaifenesin [IV] mixture. adrenaline [I] in the first mixture was determined by coupling with 5-diazo-l,2,4-triazolo-3-carboxylic acid [DTCA] reagent in alkaline medium forming fluorigenic product which can be measured at 340 nm [lambda ex. 245 nm], while procaine hydrochloride [II] gave no fluorescence. salbutamol sulfate [III] was analyzed by reaction with ethyl acetoacetate [eaa] forming coumarin derivative, which can be measured at 320 nm lambda ex. 280 nm]. guaifenesin [iv], the second drug in mixture has a considerable native fluorescence in methanol was measured at 310 nm [lambda ex. 230 nm]. all variables affecting reaction conditions were optimized. linear correlations were obtained over the range of 19-100, 37-400 and 22-150 ng/ml for [I], [III] and [IV], respectively. the proposed methods were successfully applied for the analysis of the studied drugs in their pure and commercial dosage forms and the obtained results were in good agreement with those obtained from the reported methods; no significant difference in the accuracy and precision as revealed by the accepted values of t-and f-tests, respectively


Subject(s)
Chemistry, Pharmaceutical , Epinephrine , Spectrometry, Fluorescence
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