ABSTRACT
Purpose: propofol is one of the most common drugs used in anesthesia induction and the pain during its intravenous injection is one of the most important side effects that it has. The re fore, many methods and drugs have been examined so far to reduce or eliminate this side effect. In this study a lot the effects of Alfentani l, Magnesium Sulfate and Ketamine drugs on reducing the pain during intravenous injection of Propofol are investigated
Materials and Methods: this study was performed on 220 patients who underwent orthopedic surgeries in Poursina hospital in 2010. The intens ity of Propofol intravenous injection pain is measured after using premedication by Visula Analog ueScale [VAS]. The results are analyzed using Chi square and Post hoc tests
Results: according to the gathered d a ta and analysis of variance statistic tests, we found that after Propofo l injection there is a meaningful difference in quantity of VAS score among the studied groups [Chi square = 49. 78 and df = 3 and P = .000 I]. According to Post hoc test the VAS score in Magnesium Sulfate group has a meaningful d iffe rence in comparison to other groups, while there is no meaningfu l difference among other groups [P = .05]
Conclusion: despite the reduction the Propofo l intravenous injection pain in three studied drugs in this thesis, there is no preference among them