ABSTRACT
Background: Uterine leiomyomas [myomas] are the most frequent benign uterine tumors, several studies have suggested that each leiomyoma arises from a single neoplastic cell within the smooth muscle of myometrium and in 4 percent of pregnant women, sonographically detectable myomas are present
Methods and Materials: A cohort study done in years of 1385-86 to compare obstetric outcomes between normal pregnant and pregnant women with myomas, 87 pregnant with myoma and 375 normal pregnant selected for pre, intra and post partum complications
Results: Myoma in pregnancy is a risk factor for first trimester bleeding, spontaneous first trimester abortion, placenta previa, noncephalic presentation, post partum hemorrhage and cesarean delivery but frequency of preterm labor, premature rupture of membrane, placental abruption and intra uterine growth restriction were not different between group with myoma and control group. Furthermore the rate of post partum hemorrhage in group with myoma larger than 5cm in diameter was greater than in group with myoma 5cm or smaller in diameter [P=0.02]. After multiple logistic regression analysis, advanced maternal age, nulliparity were independently associated with presence of myoma in pregnancy
Conclusion: Presence of myoma documented by gestational sonography is associated with high risk pregnancies which necessitate patient education and labor staff preparation for intra and post partum probable complications controlling