ABSTRACT
Objective: to evaluate the efficacy of the combination therapy of mometasone and pimecrolimus in the treatment of vitiligo in children
Methods: in this double-blind randomized controlled trial, 50 patients were enrolled. Based on the planned treatment protocol, three lesions with approximately identical size at similar anatomic sites were selected in each patient. Lesions were divided to three groups: pimecrolimus cream 1 % [twice a day], mometasone furoate ointment 0.1 % [every night], and combined therapy group [pimecrolimus twice a day on weekdays and mometasone every night on weekends], all being applied for three months. They were followed up for three months
Results: forty patients [with 46% of cases being male] with a mean age of 10.6 years completed the study. There was no significant difference in response rate between three groups at the end of the treatment
Conclusion: our study results did not demonstrate significant difference in the response rate and adverse effects between combined treatment group and either alone
ABSTRACT
Objective To evaluate the efficacy of niosomal dapsone gel and intralesional meglumine antimoniate with cryotherapy and intralesional meglumine antimoniate in cutaneous leishmaniasis
Methods This was a randomized clinical trial with 73 participants that were divided into two groups including, case group [weekly intralesional meglumine antimoniate and twice a day niosomal dapsone gel] and control group [weekly intralesional meglumine antimoniate with biweekly cryotherapy]. The treatment course continued until 16 weeks or complete cure, whatever occurred earlier and participants were followed up in 4th, 8th, 12th and 16th weeks of the treatment
Results Overall, 68 patients [33 males and 35 female] completed the study. Age, sex, size and duration of the lesions were not statistically different between two groups. At the end of the study, 82.9% of patients in case group showed complete response
Conclusion Niosomal dapsone gel has promising results with fewer adverse effects, so, it can be used as an alternative treatment modality, especially in children and patients with contraindication of systemic drugs
ABSTRACT
Background: There is disagreement on the effect of diabetes on oral hygiene. The purpose of this study was to assess the oral health and hygiene status of type 1 diabetic patients
Methods: In this case control study, periodontal health and hygiene of 80 children and adolescents [5-18 yr of age] with type 1 diabetes mellitus referred to Pediatric Endocrine Clinic of Besat Hospital Hamadan Iran 2013 - 2014 and 80 non diabetic control subjects were clinically assessed. The required data such as sex, age, duration of the diabetes, type and number of insulin injections per day were obtained from self-administered questionnaire and the patient's medical records. Participants in both groups were examined for Decay-missing- filled teeth [DMFT]; dmft [or primary teeth], oral hygiene using O'Leary plaque index [PI] and gingivitis index [Gl]. P<0.05 was considered significant
Results: The mean age of the study and the control group was 12.5+/-4.05 and 12.08+/-3.47 yr, respectively. There were no significant difference between two groups in terms of DMFT [P=0.158] and PI indices [P=0.373]. The Gl index difference was statistically significant in diabetic group [P=0.001]. Interestingly, a higher dmft index was observed in the control group [F=0.008]. In diabetic groups, Gl and DMFT index increased significantly with duration of diabetes
Conclusions: Apart from higher scores of Gl index, frequency of oral and periodontal disease was not different in diabetic patients compared with healthy subjects. Findings of present study are insufficient to support a significant effect of diabetes on increasing the risk of oral and periodontal diseases. However, diabetic children and adolescents should receive oral hygiene instructions