ABSTRACT
Background and Objectives: Multidrug-Resistant Tuberculosis [MDR-TB] has been lead to complexity in succesfull treatment of Tuberculosis [TB]. The aim of this study was to determine the pattern of first and second line drug resistance on pulmonary TB pateints and study their demografic and clinical links
Materials and Methods: In a cross-sectional study in 2011-2012, 105 Mycobacterium Tuberculosis [M.TB] pateints were collected randomly from east azerbayjan province of Iran. After full clinical history and physical evaluation, standard proportion method was performed for detection of drug resistance in M.TB patients
Results: Frequency distribution of the M.TB in various parts of the city was significantly different. The total prevalence of resistance to any drug was 8.57% [6.1% in new cases and 33.3% in previously treated cases]. Two [1.9%] patients were MDR-TB and a case was Extensively Drug-Resistant [XDR]. In the multiple logistic regrassion analysis, odds of resistance to one or more TB drug was significantly more in retreatment group than newly diagnosed group [OR=7.7]. Frequency of resistance to Streptomycin [5.7%] was the highest and resistance to Etambutol was the lowest [0.95%]. Sputum [88.3%] and coughing [86.4%] were the most common symptoms
Conclusion: Monitoring of drug resistance status by rapid teqnniques is necessary and crucial on patients with previous history of TB. Unexpected distribution of the disease in different parts of the city indicates the need for otherstudies
ABSTRACT
Background: Identifying the factors associated with the recurrence of Mycobacterium tuberculosis (MTB) can help in tuberculosis disease prevention and reducing the burden on the health care system. This study was designed to identify the factors associated with recurrence in MTB patients in five border provinces of Iran. Methods: In a cross-sectional study (2010 to 2012), clinical, economic, and social factors associated with the recurrence of tuberculosis were evaluated. The data were collected by a questionnaire and survey of medical records. Simple and multiple logistic regression analyses were performed using SPSS V.18. Results: A total of 300 patients with an average age of 51.9 years (SD 24.2) were randomly selected. Overall, 7.2% of the patients were diagnosed with a recurrence of tuberculosis. Sixty-four percent (n = 151) of the patients were in a low-income class. The migration from a village to a city (OR = 8.4) and weight loss (OR = 1.5) were significantly associated with an increased chance of recurrence. Conclusion: In this study, the selected provinces of Iran had moderate rates of tuberculosis recurrence in comparison to global reports. Further studies on the relationship of both weight loss and the immigration from a village to a city with tuberculosis recurrence are necessary.