ABSTRACT
Today with an increasing frequency of HIV infection around the world, its epidemiological studies is becoming more important. This study aimed to evaluate the cervical smear in human immunodeficiency virus [HIV] infected patients and also its association with CD4 counts among an Iranian population. In a case-control study, 247 women, 58 HIV infected cases and 189 healthy controls, were included. Liquid-based cytology cervical smears and hematologic findings were compared between cases and controls. The frequency of abnormal smear was significantly higher in cases 20.7% compared with controls 3.2% [p<0.001]. The mean CD4 count was significantly lower in cases with abnormal smear compared with cases with normal smear [573.0 +/- 306.9 vs. 383.7 +/- 123.6; p=0.042]. Undertaking a serious effort toward provision of gynecological care and cervical cancer screening at the same health center as HIV care, in Iranian HIV infected women is suggested
ABSTRACT
To evaluate the association between cervical squamous intraepithelial lesions [SIL] and the human immunodeficiency virus [HIV] infection and CD4 counts among an Iranian population. Case-control study. North and East Tehran Health Centers, related to Shaheed Beheshti Medical University, Iran. Two hundred forty seven women including 58 HIV infected cases and 189 healthy controls recruited between 2007 and 2010. None. Cytology-based cervical Pap smears and hematologic findings were compared between cases and controls. The prevalence of abnormal smear was significantly higher in the study group [36.2%, 15 LSIL + 6 HSIL] compared with controls [3.2%, 6 ASCUS] [p < 0.001, OR = 2.4, 95% CI 1.2 - 4.6]. The mean of CD4 count was significantly lower in cases with abnormal smear compared with cases with normal smear [573.0 +/- 306.9 Vs 383.7 +/- 123.6; p = 0.042]. Our results suggest the need for undertaking a serious effort towards the provision of gynecological care and cervical cancer screening at the same health center as HIV care, in Iranian HIV infected women