ABSTRACT
Objective: Bone marrow and umbilical cord stromal cells are multipotential stem cells that have the ability to produce growth factors that play an important role in survival and generation of axons. The goal of this study was to evaluate the effects of the two different mesenchymal stem cells on peripheral nerve regeneration
Materials and Methods: In this experimental study, a 10 mm segment of the left sciatic nerve of male Wistar rats [250-300 g] was removed with a silicone tube interposed into this nerve gap. Bone marrow stromal cells [BMSCs] and human umbilical cord stromal cells [HUCSCs] were respectively obtained from rat and human. The cells were separately cultured and transplanted into the nerve gap. The sciatic nerve regeneration was evaluated by immunohistochemistry, and light and electron microscopy. Moreover, histomorphology of the gastrocnemius muscle was observed
Results: The nerve regeneration in the BMSCs and HUCSCs groups that had received the stem cells was significantly more favorable than the control group. In addition, the BMSCs group was significantly more favorable than the HUCSCs group [P<0.05]
Conclusion: The results of this study suggest that both homograft BMSCs and heterograft HUCSCs may have the potential to regenerate peripheral nerve injury and transplantation of BMSCs may be more effective than HUCSCs in rat
ABSTRACT
Cardiac diseases are psycho-somatic disorders, and psychological aspects play an essential role in their initiation and exacerbation. The aim of this study was to gain appropriate knowledge in the epidemiology of co-morbid depression and anxiety disorder in cardiovascular outpatients. This study is descriptive with a sample of patients attending a cardio-vascular clinic. 238 individuals were included in this study using a consecutive sampling method. The study instrument was Hospital Anxiety and Depression Scale [HADS] questionnaire, which is a clinical scale for assessing anxiety and depression. Of the 238 participants in this study, 93[38.7%] were male and 146 [61.3%] female. 28.5% of patients suffered from anxiety disorders, and 41.9% had depression. Regarding comorbid diseases such as diabetes mellitus, hyperlipidemia and hypertension, the severity of depression was just related to hypertension. There was a meaningful relationship between gender and symptoms of anxiety so that symptoms were more severe in women. Considering the high prevalence of depression and anxiety in patients suffering from cardio-vascular diseases, it is necessary to screen psychological disorders in patients with cardio-vascular diseases and improve their cardio-vascular health and quality of life as mush as possible