ABSTRACT
Statement of the Problem: Recurrent aphthous stomatitis [RAS] is one of the most common lesions in the oral cavity. Due to its multifactorial nature, there is no definitive treatment for RAS. Laser therapy is one of the suggested treatments to reduce patient's discomfort
Purpose: The purpose of the present clinical trial is to assess the effect of low and high level laser therapy on pain control and wound healing of RAS
Materials and Method: Thirty six patients with minor RAS were divided into three groups. Group 1 [n=14] received CO[2] laser, group 2 [n=12] were treated with In-GaAlP Diode laser and group 3 [n=10] received sham laser as placebo. All patients were evaluated daily up to 15 days after receiving one session of laser therapy. Pain severity before and after treatment, wound healing, patient's satisfaction, and functional disturbance before and after treatment were recorded for each patient
Results: According to statistical analysis, pain reduction after treatment in group 1 was 7.00+/-2.41, in group 2 was 2.08+/-2.31, and in group 3 was 1.40+/-1.77. In addition, a significant difference was observed in the reduction of functional complications in CO[2] laser treated patients compared to the other two groups
Conclusion: High-level laser treatment showed analgesic effects on RAS, but no healing was observed. Low-level laser therapy demonstrated no positive effect on recurrent aphthous ulcers
ABSTRACT
Statement of the Problem: Oral cancer is among the ten most common cancers worldwide. It affects the life quality of patients in many ways
Purpose: The aim of this study was to compare the effects of two different systemic doses of Viola Odorata syrup on the prevention of 4-Nitroquinoline-1-oxide [4- NQO] induced tongue dysplasia in rats
Materials and Method: Forty-eight male Wistar rats were divided into four groups of A, B, C and D. Group A served as the control group. The rats in groups B to D received 30 ppm of 4-NQO in drinking water for 12 weeks. Additionally, the rats in groups B and C received Viola Odorata syrup at doses of 15 and 5 ml/kg, respectively, 3 times a week. Body weights were measured three times a week. At the end, the rats were euthanized and the tongue was removed. Histological evaluations for carcinogenesis were carried out under a light microscope
Results: The mean body weight of the rats in groups B, C, and D were lower than that in group A [p< 0.01]. After 12 weeks of treatment, microscopically no histological changes of the tongue base epithelia were observed in the control group. The rats in group B did not show severe dysplastic changes; only mild to moderate histological changes including hyperplasia and hyperkeratosis were evident. These incidences were significantly more apparent in groups C with moderate to severe changes [p< 0.05] and group D with severe dysplastic changes [p< 0.01]. Almost all rats in group D had hyperplasia and manifested all of the stages of dysplasia
Conclusion: Viola Odorata extract has dose-dependent inhibitory effects on the development of tongue induced dysplasia
ABSTRACT
Background: Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with treatment challenges for clinicians. Aims: The objective of this study is to compare the effects of cryotherapy as a new modality with topical corticosteroids as a conventional therapy in the treatment of OLP. Materials and Methods: Thirty patients with bilateral OLP lesions were selected. From each patient a lesion on one side was chosen randomly for a single session of cryotherapy with nitrous oxide gas and the lesion on the other side received triamcinolone acetonide 0.1% ointment in orabase. Treatment outcome was measured by means of an appearance score, pain score (visual analogue scale), and severity of lesions before treatment and after 2, 4 and 6 weeks of treatment. Statistical Analysis Used: Paired samples t‑test and Wilcoxon test. Results: In both methods of treatment sign score, pain score and severity of lesions was significantly reduced in all follow‑up sessions (P < 0.05). But the treatment outcome and relapse was not significantly different between the two treatment methods (P > 0.05). Conclusion: Cryotherapy with nitrous oxide gas is as effective as topical triamcinolone acetonide in the treatment of OLP with no systemic side effects and needs less patient compliance. It can be considered as an alternative or adjuvant therapy in OLP patients to reduce the use of treatments with adverse effects.