ABSTRACT
To assess whether bromocriptine-rebound method [BRM] can improve pregnancy outcomes compared to long protocol after intracytoplasmic sperm injection cycles [ICSIs]. A total of 114 women underwent ICSI. Pregnancy outcomes and hormonal data were compared between two groups, i.e. long protocol and BRM. Ovulatory women with normal serum prolactin levels were assigned to either BRM [n = 57 cycles] or long protocol [n = 57 cycles]. Both procedures were carried out in a similar way. However, a group of patients were given bromocriptine daily from the 4[th] day of the preceding cycle until 7 days before gonadotropin stimulation. There were no significant differences in the numbers of developed follicles, total retrieval oocytes, transferred embryo and embryos with superior morphology between the two groups. Also, the values of chemical, clinical and ongoing pregnancies and live births were not significantly different [36.8%, 35.1%, 28.1%, 28.1% in BRM group and 43.9%, 38.6%, 21.1% and 19.3% in long protocol, respectively]. Ongoing pregnancy and live birth were significantly higher in chemical pregnancy in the BRM group [P = .04 and P = .035, respectively]. This prospective study demonstrated that BRM might lead to higher ongoing pregnancy and live birth rates compared to the long protocol in women undergoing intracytoplasmic sperm injection cycles
ABSTRACT
Type 2 receptors for vascular endothelial growth factor are believed to be involved in the pathophysiology of ovarian hyper-stimulation syndrome [OHSS]. The objective of this study was to examine the preventive effects of cabergoline on OHSS and its complications. The study is a non randomized clinical trial conducted in 2006-2008 on 75 patients, which were at risk of OHSS and underwent assisted reproductive techniques. The diagnosis and severity of OHSS were determined using standard criteria. The study included an intervention and a control group. The intervention group comprised of 50 women at risk of OHSS, who were treated with cabergoline [1mg every other day for 8 days] commencing from the day of ovum pick up. The control group comprised of 35 historical cases, which were similar to the case group. The latter group did not receive cabergoline, and their OHSS, if occurred, were managed conservatively after hospital admission. The rates of OHSS, baseline characteristics, ovarian stimulation parameters, and pregnancy occurrence were compared. There was no significant difference between baseline characteristics or ovarian stimulation parameters from the two groups. The incidence of OHSS in the cabergoline-treated group, was significant [P=0.01] lower than that in the control group [12% vs 36%]. Embryo freezing was significantly [P=0.001] lower in the cabergoline group. The findings of the study indicate that cabergoline reduces the incidence of OHSS, and is not associated with adverse effects on pregnancy
ABSTRACT
Anti-mullerian hormone [AMH] levels may represent the ovarian follicular pool and could be a useful marker of ovarian reserve. The clinical application of AMH measurement has been proposed in the prediction of quantitative and qualitative aspects in assisted reproductive technologies. This study aimed to assess the relationship between the serum levels of AMH and results of assisted reproductive technique [ART] outcome in polycystic ovary syndrome [PCOS] patients versus control group. This cohort study was conducted on 61 [PCOS] patients and 28 patients without PCOS [controls] candidates for assisted reproductive technique. Serum levels of AMH were measured on the 3[rd] day of menstrual cycle and all the patients underwent controlled ovarian hyper stimulation and ART. The relationship between AMH serum level with retrieved oocytes, mature oocytes and pregnancy rate were assessed. There was significant correlation between the AMH level with number of total retrieved oocytes and mature oocytes in patients with PCOS and controls [p=0.001]. In PCOS and control groups AMH level in pregnant patients was higher, but it was not statically significant [p=0.65, p=0.46, respectively]. The major outcome of the study [pregnancy] did not differ significantly between two groups. This study revealed that AMH level was higher in pregnant patients undergoing ART; but AMH may not be an accurate predictor for pregnancy in PCOS patients
Subject(s)
Humans , Female , Reproductive Techniques, Assisted , Polycystic Ovary Syndrome , Treatment Outcome , Cohort Studies , OocytesABSTRACT
Female sexual dysfunction [FSD] is a real problem that affects 25-63% of women. There is no valid Persian version of sexual function questionnaire [FSQ]. The aim of this study was to test the reliability and validity of Persian version of sexual function questionnaire. In this cross-sectional study, 547 women were questioned by Persian version of SFQ. Factor analysis produced five domains of female sexual function. Internal consistency, test-retest reliability, and discriminant validity were calculated. Five-factor structure accounted for 63% of the variance. Arousal-orgasm domain was as same as arousal-sensation, arousal-lubrication, and orgasm domains of the original version. Enjoyment-desire domain was similar to enjoyment and desire domains except one question. Pain and partner domains were consistent with original domains. Internal consistency, test-retest reliability, and discriminant validity were reasonable in Persian version of SFQ. Persian version of SFQ is almost valuable and reliable to use for Iranian population with exception of one question. Results of the omitted question from enjoyment domain should interpret separately as unusual sex domain
Subject(s)
Humans , Female , Sexual Dysfunctions, Psychological , Surveys and Questionnaires , Psychometrics , Cross-Sectional StudiesABSTRACT
Background: The etiologic cause in near one third of male factor infertility is unknown. The percentage of men with idiopathic infertility who have been successfully treated by the empirical therapeutic modalities is not high
Objective: The aim of this study was to assay the effect of L-carnitine on sperm parameters in patients who needs intracytoplasmic sperm injection [ICSI] as a method for infertility treatment
Materials and Methods: The study population consisted of 65 men [mean age +/- SD: 34.4 +/- 6.07] presenting with primary infertility due to idiopathic oligoasthenoteratozoospermia. L-carnitine was prescribed Igram orally every 8 hours for 3 months. Before and after the ending of the L-carnitine treatment, semen analysis was performed
Results: The proportion of patients who had motile and grade C sperms rose significantly after treatment. Percentile of abnormal shaped sperms decreased significantly after treatment. In approximately 22%, complete asthenozoospermia changed to relative asthenozoospermia
Conclusion: Appearing motile sperms will potentially improve the technique of ICSI. The magnitude of the elevation in normal morphology is not clinically obvious, but it seems that it can be important in obtaining normal-shaped sperms for intracytoplasmic injection. Designing a study on selected patients with complete asthenozoospermia who have not other abnormalities in semen parameters can reveal the real effect of carnitine therapy in this category