CXC Ligand 5 cytokine serum level in women with polycystic ovary syndrome and normal body mass index: a case-control study

Background: Polycystic ovary syndrome [PCOS] is the most common endocrine disease and associated with insulin resistance. CXC Ligand 5 [CXCL5] is a new cytokine which is secreted from white adipose tissue during obesity and by blocking insulin signaling pathway inhibits the activity of insulin and promotes insulin resistance

Objective: The aim of this study was to assess serum level of CXCL5 in PCOS women with normal body mass index

Materials and Methods: In this case-control study, 30 PCOS women with normal body mass index as the case group and 30 non-PCOS women as the controls were enrolled. Serum levels of CXCL5, insulin and other hormones factors related with PCOS were measured by ELISA method, also the biochemical parameters were measured by auto analyzer

Results: Significant increases in serum insulin concentration, homeostasis model assessments of insulin resistance, luteinizing hormone, luteinizing hormone/follicle-stimulating hormone, fasting blood sugar, testosterone, and prolactin were observed in the case group compared to the controls. were in the serum level of CXCL5, cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, dehydroepi and roster one-sulfate, creatinine, and homeostasis model assessment of beta cell function between these two groups

Conclusion: In this study, no significant change was observed in serum concentrations of CXCL5 in PCOS women with normal BMI

study of the effects of post treatment with rosmarinus officinalis aqueous extract the first 48 hours after renal ischemia/reperfusion in rats

Acute renal failure induced by ischemia / reperfusion [I/R] causes excretory functional disorders of nephrons. The purpose of this study is to evaluate the intake of oral rosemary extract [gavage] on hemodynamic changes and tissue damages caused by I/R. This study was conducted on 40 Sprague-Dawley male rats, composed of 4 groups [n=10] including control, sham, I/R+normal saline [I/R+NS] posttreatment and I/R+rosemary [I/R+RO] post-treatment. They were fed with 10 ml/kg of 8% aqueous extract or vehicle as gavages during the first 48 hours after I/R. To induce I/R, both renal artery and vein were blocked for 30 minutes followed by a reperfusion within 48 hours. Then urine and plasma samples were collected and histological study was also conducted after removal of both kidneys. Data were analyzed by SPSS-11.5 software. The one-way analysis of variance [ANOVA] and Duncan test were used for intergroup comparison and p