Successful Treatment of an Aortoesophageal Fistula after Open Stent Grafting of a Right Aortic Arch and a Descending Aortic Aneurysm Rupture / 日本心臓血管外科学会雑誌

A 52-year-old man suffered from rupture of a right aortic arch and a descending aortic aneurysm. The patient was treated with an open stent grafting technique, and complete revascularization was achieved. Twelve days after the operation, a computed tomographic scan revealed a fistula between the distal esophagus and the excluded aneurysm sac. Twenty-six days later, the patient was treated by an esophagectomy, a cervical esophagogastrostomy, as well as a feeding jejunostomy. The infectious parietal thrombus was partially debrided, and the aneurysm sac was filled with omentum. The patient recovered uneventfully. The patient has been followed for 18 months with no signs of infection.

A Successful Case of Open Stent-Grafting for an Impending Ruptured Acute Type B Aortic Dissection / 日本心臓血管外科学会雑誌

A 70-year-old man was admitted suffering from chest and back pain. He was assessed by enhanced computed tomography (eCT) and a thrombosed acute DeBakey type IIIb aortic dissection with an ulcer like projection (ULP) was diagnosed and treated medically. Five days later, he complained suddenly of dyspnea and was diagnosed by eCT as having a pulmonary thromboembolism. Anticoagulant therapy was started reluctantly. The patient's symptoms improved, however, 16 days later he complained of severe chest and back pain. Enhanced CT showed enlargement of the ULP, which was diagnosed as an impending aortic rupture. Open stent-grafting was selected as a less-invasive treatment method. A stent-graft was introduced into the descending aorta via the transected aortic arch and the entry of the ULP was closed. Postoperative course was smooth and uneventful. We consider that open stent-grafting via the aortic arch is an alternative method for repair of acute type B aortic dissection with an ULP in the descending aorta, in cases where direct closure of the intimal tear is difficult.

Outcome and Problem of Ruptured Abdominal Aortic Aneurysms in Octogenarians / 日本心臓血管外科学会雑誌

Ruptured abdominal aortic aneurysms (RAAA) can be lethal unless appropriate diagnosis and immediate repair are made. Since advanced age is a surgical risk, however, octogenarians are considered as poorer candidates for elective surgical intervention before rupture. The aims of this study were to clarify the problems and factors that are associated with mortality from RAAA in elderly patients. A retrospective study of all infrarenal RAAA patients (<i>n</i>=126) who presented at our center between 1985 and 2003 is presented. The patients were classified into 2 groups, Group O included 37 RAAA patients (male:female=22:15) aged 80 years old or over, and Group Y included 89 RAAA patients (male:female=70:19) under 80 years old. We analyzed and compared preoperative, operative, and postoperative states between groups. The percentage of cardiopulmonary arrests (CPA) was significantly higher in Group O (14/37, 38%) than in Group Y (24/89, 27%). The other preoperative factors (time to reach hospital, time in shock, blood pressure, base excess, hemoglobin, blood urea nitrogen, creatinine, aneurysmal size) were not significantly different between the groups. The operative factors (operation time, aortic clamp time, the amounts of urine output and bleeding during the operation) were not significantly different between the groups. The rates of postoperative complications did not significantly differ between the groups. In a comparison of all cases, including patients with CPA, the survival rate was significantly lower in Group O (14/37, 37.8%) compared with Group Y (55/89, 61.8%). On the other hand, for the patients who underwent prosthetic graft replacement, the survival rate was equivalent in Group O (14/18, 77.8%) and Group Y (55/75, 73.3%). The mortality rate and percentage of CPA in Group O were significantly higher than in Group Y although the preoperative, operative and postoperative statistics are not significantly different. For patients who undergo prosthetic graft replacement, the survival rate is equivalent. These findings suggest that octogenarian patients cannot withstand the hypovolemic shock that is due to RAAA. We recommend elective operation before rupture in elderly patients with AAA.

Prognosis of Stanford Type B Acute Aortic Dissection and Availability of Early Rehabilitation Program in Medical Treatment / 日本心臓血管外科学会雑誌

Stanford type B acute aortic dissection without complications has been considered to be an indication for medical rather than surgical treatment. To investigate the availability of medical treatment and early rehabilitation, we evaluated 90 cases treated between 1986 and 1999 with type B acute aortic dissection. These consisted of 79 nonruptured cases and 11 ruptured cases at the beginning of treatment in our medical center. No surgery was performed in any of the nonruptured cases but surgery was performed in 8 of 11 ruptured cases. Surgical mortality in the rupture type was 12.5% (1/8). During medical treatment of the nonrupture type, 3 patients died of sudden rupture (1 case) and bowel ischemia (2 cases). An early rehabilitation program in which the goal was for the patient to walk around the ward within 2 weeks was performed for 31 consecutive cases of nonrupture type without vascular complications. Mortality was not significantly different between the early and conventional rehabilitation groups. The incidence of pneumonia and ICU syndrome during medical treatment was 13.0% (6/46) and 37% (17/46), respectively in the conventional group and 0% and 12.9% (4/31), respectively in the early group. The incidence of ICU syndrome was significantly lower in the early group than in the conventional group. Despite the limitations of this study, medical treatment and early rehabilitation showed good results in cases of uncomplicated type B acute aortic dissection.

Appropriate Protamine Administration to Neutralize Heparin after Cardiopulmonary Bypass Using the Hepcon/HMS / 日本心臓血管外科学会雑誌

We reevaluated our heparin and protamine administration protocol during and after cardiopulmonary bypass (CPB). In 12 patients who underwent cardiac surgery using a heparin-coated circuit under mild hypothermia, heparin concentration was measured with the Hepcon^®/HMS. Before initiating CPB, 1.5mg/kg of heparin was given to maintain the activated clotting time (ACT) at more than 400sec. Patients were divided into two groups. In group I (<i>n</i>=6), heparin was neutralized with an empirical dose of protamine (1.5mg protamine/mg initial heparin). In group II (<i>n</i>=6), the protamine dose was determined by the residual heparin concentration, measured with the Hepcon^®. Patients in group II received a lower dosage of protamine than group I (1.7±0.0 vs. 3.6±0.4mg/kg, <i>p</i><0.001). There were no significant differences in the intraoperative bleeding, postoperative bleeding and activated clotting time between the groups. By determining the appropriate protamine dosage, this heparin analysis system may be useful in managing CPB.

Outcome of Ruptured Abdominal Aortic Aneurysms in Patients over 80 Years Old / 日本心臓血管外科学会雑誌

The hospital records of 59 patients treated for ruptured abdominal aortic aneurysms during the past eleven years were reviewed. The patients were classified into two groups: an elderly group aged 80 years old or wore (18 cases) and a control group aged under 80 years old (41 cases). Previous diagnoses of abdominal aortic aneurysm had been made more frequently in the aged group (44.4%) than in the control group (22%). Of the patients who fell into shock preoperatively, only 6 patients (60%) received graft replacements in the aged group, but all patients received graft replacements in the control group. Graft replacements were performed as safely in non-shock patients in the elderly group as in cases of non-ruptured abdominal aortic aneurysm. The overall survival rate including non-operative cases in the elderly group (38.9%) was lower than that in the control group (61%). The survival rates in patients receiving graft replacemes showed no significant difference between the elderly group (63.3%) and the control group (67.6%). Many of the aged patients who fell into shock due to aortic rupture died without receiving surgery. Hypovolemic shock which results in ischemia in vital organs is the most likely major cause of death in patients of advanced age. In conclusion, graft replacements should be performed electively and safely before aneurysmal rupture, particularly in elderly patients.